Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses
| Autor: | John Gilchrist, William Schroeder, William A. Muller, Ranajana Unnithan, Merideth A. Early, Alan R. Schenkel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Leukocyte migration Population Immunology Contact Hypersensitivity lcsh:Medicine Dermatology γδT lymphocytes General Biochemistry Genetics and Molecular Biology Monocytes Emigration 03 medical and health sciences 0302 clinical medicine Dinitrofluorobenzene medicine Platelet education Lymphocyte homing receptor education.field_of_study Effector Chemistry General Neuroscience lcsh:R General Medicine Cell Biology Leukocyte medicine.disease CD4+ T lymphocytes Natural Killer Lymphocytes Endothelial stem cell Platelet Endothelial Cell Adhesion Molecule-1 030104 developmental biology cardiovascular system General Agricultural and Biological Sciences Infiltration (medical) 030215 immunology Granulocytes |
| Zdroj: | PeerJ, Vol 5, p e3555 (2017) PeerJ |
| ISSN: | 2167-8359 |
| Popis: | Background 2′–4′ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1 in the migration capacity of several different leukocyte populations after primary and secondary application. Results γδ T lymphocytes, granulocytes, and Natural Killer cells were most affected by PECAM-1 deficiency at the primary site of application. γδ T lymphocytes, granulocytes, DX5+ Natural Killer cells, and, interestingly, effector CD4+ T lymphocytes were most affected by the loss of PECAM-1 at the secondary site of application. Conclusions PECAM-1 is used by many leukocyte populations for migration, but there are clearly differential effects on the usage by each subset. Further, the overall kinetics of each population varied between primary and secondary application, with large relative increases in γδ T lymphocytes during the secondary response. |
| Databáze: | OpenAIRE |
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