Comparison of immune reconstitution after allogeneic vs. autologous stem cell transplantation in 182 pediatric recipients
| Autor: | M. Eyrich, P.G. Schlegel, Verena Wiegering, B. Winkler |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_treatment
Pediatric patients chemical and pharmacologic phenomena Hematopoietic stem cell transplantation 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Immune system immune system diseases hemic and lymphatic diseases Medicine business.industry Stem cell transplantation lcsh:RJ1-570 lcsh:Pediatrics Autologous hsct Hematology Immune reconstitution surgical procedures operative Oncology 030220 oncology & carcinogenesis Allogeneic hsct Pediatrics Perinatology and Child Health Time course Immunology business therapeutics 030215 immunology Lymphocyte subsets |
| Zdroj: | Pediatric Hematology Oncology Journal, Vol 2, Iss 1, Pp 2-6 (2017) |
| ISSN: | 2468-1245 |
| Popis: | Background Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for children with a variety of malignant and non-malignant conditions. However, even if immune reconstitution after HSCT has been studied in extensively, until now data on the comparison of immune reconstitution after autologous vs. allogeneic HSCT is scarce, but might provide important clinical implications. Patient and methods We examined immune reconstitution (T-, B-and NK-cells) at defined time points in 147 children who received 182 HSCT. Differences in the time course of immune reconstitution were analyzed in autologous vs. allogeneic HSCT. Results We identified a quicker immune reconstitution in the T-cell compartment, especially in the CD4 and naive subset after autologous HSCT, whereas recipients of allogeneic transplants showed a higher TCRgd proportion. B-cell reconstitution showed a delayed immune reconstitution after allogeneic HSCT in the first two years after HSCT. However, a reconstitution of all lymphocyte subsets after HSCT could be achieved in all patients. Conclusion Children undergoing a HSCT show a different pattern of immune reconstitution in the allogeneic and autologous setting. This might influence the outcome and should affect the clinical handling of infectious prophylaxis and re-vaccinations. |
| Databáze: | OpenAIRE |
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