The Effect of Some Ionized and Neutral Surfactants and Bile Acids upon Sodium and Water Transport from Tied Jejunal Loops in Anaesthetized Rats
| Autor: | Reidar Bredo Sund |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Cell Membrane Permeability Absorption of water medicine.medical_treatment Sodium Hypertonic Solutions Biological Transport Active chemistry.chemical_element Toxicology Bile Acids and Salts Surface-Active Agents Benzalkonium chloride chemistry.chemical_compound Body Water Pulmonary surfactant medicine Animals Saline Cetrimonium bromide Pharmacology Chromatography Water transport Chemistry Osmolar Concentration Cholic acid Water-Electrolyte Balance Stimulation Chemical Rats Jejunum Hypotonic Solutions medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 37:297-308 |
| ISSN: | 0001-6683 |
| Popis: | Surfactants of diverse types, viz. dioctylsulphosuccinate, cetrimonium bromide, benzalkonium chloride, Lubrol$rG WX, Triton$rG X100, desoxicholic acid, cholic acid and glycodesoxicholic acid all affected jejunal transport of sodium and water in the same way as previously shown for dodecylsulphate: From hypotonic sodium chloride solutions, they inhibited net water absorption or induced secretion in a dose dependent manner; from hypertonic sodium salt solutions net sodium absorption was enhanced. The results indicate that, with increasing doses of surfactant, diffusion becomes increasingly important as the determinant of net sodium transport, suggesting that the surfactants cause increased passive permeability of the intestinal epithelium. Taurodesoxicholic acid caused inhibition when tested with hypotonic saline, and by analogy is assumed to act in the same way as the above mentioned surfactants. Some of the non-ionic surfactants tested did not influence jejunal transport. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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