Polycythemia Vera and Essential Thrombocythemia Patients Exhibit Unique Serum Metabolic Profiles Compared to Healthy Individuals and Secondary Thrombocytosis Patients

Autor: Leonor Puchades-Carrasco, Joaquin Martinez-Lopez, Beatriz Bellosillo, Nuria Gómez-Cebrián, Carlos Besses, Antonio Pineda-Lucena, Arturo Albors-Vaquer, Ayelén Rojas-Benedicto
Rok vydání: 2021
Předmět:
0301 basic medicine
Cancer Research
medicine.medical_specialty
Metabolic profile
Creatine
lcsh:RC254-282
Article
myeloproliferative neoplasms
Myeloproliferative neoplasms
Nuclear magnetic resonance
Oncología
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Metabolomics
Polycythemia vera
Internal medicine
hemic and lymphatic diseases
medicine
Hematología
chemistry.chemical_classification
metabolic profile
metabolomics
myeloproliferative neoplasms
nuclear magnetic resonance
Essential thrombocythemia
business.industry
Lipid metabolism
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
metabolomics
metabolic profile
nuclear magnetic resonance
030104 developmental biology
Acetoacetic acid
Endocrinology
Oncology
chemistry
030220 oncology & carcinogenesis
Isoleucine
business
Polyunsaturated fatty acid
Zdroj: E-Prints Complutense. Archivo Institucional de la UCM
instname
Cancers
Volume 13
Issue 3
Dadun. Depósito Académico Digital de la Universidad de Navarra
Consejo Superior de Investigaciones Científicas (CSIC)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Cancers, Vol 13, Iss 482, p 482 (2021)
ISSN: 2072-6694
Popis: Most common myeloproliferative neoplasms (MPNs) include polycythemia vera (PV) and essential thrombocythemia (ET). Accurate diagnosis of these disorders remains a clinical challenge due to the lack of specific clinical or molecular features in some patients enabling their discrimination. Metabolomics has been shown to be a powerful tool for the discrimination between different hematological diseases through the analysis of patients&rsquo
serum metabolic profiles. In this pilot study, the potential of NMR-based metabolomics to characterize the serum metabolic profile of MPNs patients (PV, ET), as well as its comparison with the metabolic profile of healthy controls (HC) and secondary thrombocytosis (ST) patients, was assessed. The metabolic profile of PV and ET patients, compared with HC, exhibited higher levels of lysine and decreased levels of acetoacetic acid, glutamate, polyunsaturated fatty acids (PUFAs), scyllo-inositol and 3-hydroxyisobutyrate. Furthermore, ET patients, compared with HC and ST patients, were characterized by decreased levels of formate, N-acetyl signals from glycoproteins (NAC) and phenylalanine, while the serum profile of PV patients, compared with HC, showed increased concentrations of lactate, isoleucine, creatine and glucose, as well as lower levels of choline-containing metabolites. The overall analysis revealed significant metabolic alterations mainly associated with energy metabolism, the TCA cycle, along with amino acid and lipid metabolism. These results underscore the potential of metabolomics for identifying metabolic alterations in the serum of MPNs patients that could contribute to improving the clinical management of these diseases.
Databáze: OpenAIRE
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