High levels of antibodies against PtpA and PknG secreted by Mycobacterium avium ssp. paratuberculosis are present in neuromyelitis optica spectrum disorder and multiple sclerosis patients
| Autor: | Giannina Arru, Elisa Caggiu, GianPietro Sechi, Marco Bo, Horacio Bach, Yael N. Slavin, Leonardo Antonio Sechi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Multiple Sclerosis Immunology Paratuberculosis Virulence Protein tyrosine phosphatase Protein Serine-Threonine Kinases Microbiology 03 medical and health sciences 0302 clinical medicine Bacterial Proteins medicine Humans Immunology and Allergy Pathogen Cells Cultured Neuromyelitis optica biology Neuromyelitis Optica Middle Aged medicine.disease biology.organism_classification Antibodies Bacterial Mycobacterium avium subsp. paratuberculosis 030104 developmental biology Secretory protein Neurology Astrocytes biology.protein Female Neurology (clinical) Protein Tyrosine Phosphatases Antibody 030217 neurology & neurosurgery Mycobacterium |
| Zdroj: | Journal of Neuroimmunology. 323:49-52 |
| ISSN: | 0165-5728 |
| Popis: | Mycobacterium avium ssp. paratuberculosis (Map) is the etiological agent of Paratuberculosis in ruminants. Protein tyrosine phosphatase A (PtpA) and protein kinase G (PknG) are secreted proteins necessary for the survival of the pathogen within macrophages. In this study we analyzed if Map was able to grow within astrocytes and investigated on the presence of antibodies against PtpA and PknG proteins in MS and NMOSD patients by ELISA. Map was unable to proliferate in astrocytes after of 72 h post-infection, but we observed a high level of antibodies against both virulence factors, suggesting that these patients have been exposed/infected with Map. |
| Databáze: | OpenAIRE |
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