Cerebrospinal fluid concentration of fibronectin in patients with HIV-1 infection and central nervous system disorders
| Autor: | G Ferrario, G Bonetta, D Torre, G P Fiori, C Zeroli, R Martegani |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty AIDS Dementia Complex Opportunistic infection AIDS-Related Opportunistic Infections Central nervous system HIV Infections Pathology and Forensic Medicine Central nervous system disease Cerebrospinal fluid Acquired immunodeficiency syndrome (AIDS) Central Nervous System Diseases Immunopathology medicine Dementia Humans business.industry Leukoencephalopathy Progressive Multifocal General Medicine Middle Aged medicine.disease Fibronectins medicine.anatomical_structure Immunology HIV-1 Female business Research Article |
| Zdroj: | Journal of clinical pathology. 46(11) |
| ISSN: | 0021-9746 |
| Popis: | AIMS--To evaluate the fibronectin concentrations in the cerebrospinal fluid of HIV-1 infected patients with central nervous system disorders. METHODS--Fibronectin was determined by an immunoturbidimetric assay in 41 HIV-1 infected patients with AIDS dementia complex, progressive multifocal leucoencephalopathy, and opportunistic infections. RESULTS--A significant decrease in fibronectin concentrations in the cerebrospinal fluid of patients with AIDS and dementia complex and progressive multifocal leucoencephalopathy was observed, as well as in those with opportunistic infections of the central nervous system (p < 0.0001). In particular, a significant decrease in fibronectin concentration in cerebrospinal fluid was observed in patients with cerebral toxoplasmosis and cryptococcal meningitis (p < 0.0001). CONCLUSIONS--Because fibronectin can bind to several viruses, fungi, and protozoa, it is conceivable to suppose that the consumption of fibronectin in the cerebrospinal fluid of patients with neurological disorders may be related to the binding of fibronectin to HIV itself, or to viral proteins, or to organisms responsible for opportunistic infections. |
| Databáze: | OpenAIRE |
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