The metabolic syndrome of ω3-depleted rats. V. Intestinal phospholipid ω6 fatty acids
| Autor: | Laurence Portois, Willy Malaisse, Yvon Carpentier, Mirjam Hacquebard |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Linseed Oil Phospholipid Jejunum Caecum chemistry.chemical_compound Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 Genetics medicine Animals Intestinal Mucosa Phospholipids Metabolic Syndrome chemistry.chemical_classification biology food and beverages General Medicine biology.organism_classification medicine.disease Molecular medicine Rats Intestines medicine.anatomical_structure Endocrinology chemistry Apoptosis Linear Models Duodenum Female lipids (amino acids peptides and proteins) Metabolic syndrome Polyunsaturated fatty acid |
| Zdroj: | International Journal of Molecular Medicine. 24 |
| ISSN: | 1107-3756 |
| DOI: | 10.3892/ijmm_00000305 |
| Popis: | This study aims mainly at investigating the effects of a dietary deprivation and replenishment of omega3 PUFA upon the phospholipid pattern of omega6 PUFA in the duodenum, jejunum, caecum and colon of rats exposed for 3-7 months to an omega3-depleted diet and then eventually exposed for 2-4 weeks to an omega3-rich diet. In control rats, the relative weight content of all omega6 fatty acids differed in the proximal and distal intestinal segments. In the omega3-depleted rats the C18:2omega6, C20:2omega6 and C20:3omega6 content was decreased whilst that of C20:4omega6 and C22:4omega6 was increased. Significant correlations were found in the caecum or colon between the C18:2omega6 or C20:4omega6 content of intestinal phospholipids and their C22:6omega3 content, an increase in the latter content coinciding with an increase in C18:2omega6 and decrease of C20:4omega6. Such was also the case for C20:4omega6, but not C18:2omega6, in the duodenum and jejunum. At these proximal intestinal levels, exposure of the omega3-depleted rats to a flaxseed oil-enriched diet indeed decreased the C18:2omega6 phospholipid content, an effect possibly attributable to the much lower content of C18:2omega6 in the latter diet, as distinct from the sunflower diet offered to the omega3-depleted rats during the first 7 months. However, at more distal intestinal levels, and like in the liver, a deficiency in omega3 fatty acids apparently favours the stepwise conversion of C18:2omega6 to C20:4omega6 and C22:4omega6. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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