Biocompatibility, encrustation and biodegradation of ofloxacine and silver nitrate coated poly-L-lactic acid stents in rabbit urethra
| Autor: | Markku Multanen, Tero Välimaa, Marita Laurila, Pertti Törmälä, Jukka Seppälä, Teuvo L.J. Tammela, Martti Talja |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Ofloxacin Biocompatibility Scanning electron microscope Urology Polyesters Anti-Infective Agents Urinary engineering.material chemistry.chemical_compound Coating Coated Materials Biocompatible Urethra medicine Copolymer Animals Adhesion Biodegradation Surgery Silver nitrate Biodegradation Environmental chemistry Biofilms engineering Microscopy Electron Scanning Silver Nitrate Stents Rabbits Crystallization Caprolactone Nuclear chemistry |
| Zdroj: | Urological research. 30(4) |
| ISSN: | 0300-5623 |
| Popis: | The purpose of this study was to evaluate the biocompatibility, encrustation and biodegradation properties of silver nitrate and ofloxacine blended caprolactone-L-lactide copolymer coated self-reinforced poly-L-lactic acid (SR-PLLA) urospirals in situ in the male rabbit urethra. SR-PLLA urospirals coated with 10% by weight silver nitrate or 5% by weight ofloxacine blended copolymer or pure copolymer were inserted into the posterior urethra of 18 male rabbits. No prophylactic antibiotics were given. The animals were sacrificed 1 or 6 months after insertion. Urethral tissue reactions were histologically scored semiquantitavely and the appearence of the stents assessed using scanning electron microscopy. The biodegradation time of SR-PLLA stents was remarkably reduced by the caprolactone coating. Silver nitrate and ofloxacine blended copolymer coated urospirals caused less tissue reaction than urospirals with a pure copolymer coating. Silver nitrate coating effectively prevented biofilm formation and stent encrustation. Silver nitrate and ofloxacine blended copolymer coated SR-PLLA urospirals had good biocompatibility properties in rabbit urethra. In particular, coating with silver nitrate may provide possibilities of preventing bacterial adhesion to bioabsorbable stents. |
| Databáze: | OpenAIRE |
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