Make Sure You Have a Safety Net: Updates in the Prevention and Management of Infectious Complications in Stem Cell Transplant Recipients

Autor:	Yoona Rhee, Michael T Czapka, Aamir S Kazi, Laurie A. Proia, Carlos A. Q. Santos
Rok vydání:	2020
Předmět:	antibacterial treatment medicine.medical_specialty lcsh:Medicine Review Neutropenia medicine.disease_cause 03 medical and health sciences Letermovir infectious complications 0302 clinical medicine Medicine 030212 general & internal medicine Intensive care medicine cytomegalovirus 0303 health sciences invasive fungal infections 030306 microbiology business.industry lcsh:R Hematopoietic stem cell General Medicine Immune dysregulation medicine.disease Transplantation medicine.anatomical_structure Graft-versus-host disease Bezlotoxumab antibacterial prophylaxis Stem cell business medicine.drug
Zdroj:	Journal of Clinical Medicine, Vol 9, Iss 3, p 865 (2020) Journal of Clinical Medicine
ISSN:	2077-0383
DOI:	10.3390/jcm9030865
Popis:	Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus host disease, which necessitates treatment with immunosuppressive medications; and placement of invasive catheters. The prevention and management of infections in these vulnerable hosts is of utmost importance and a key “safety net” in stem cell transplantation. In this review, we provide updates on the prevention and management of CMV infection; invasive fungal infections; bacterial infections; Clostridium difficile infection; and EBV, HHV-6, adenovirus and BK infections. We discuss novel drugs, such as letermovir, isavuconazole, meropenem-vaborbactam and bezlotoxumab; weigh the pros and cons of using fluoroquinolone prophylaxis during neutropenia after stem cell transplantation; and provide updates on important viral infections after hematopoietic stem cell transplant (HSCT). Optimizing the prevention and management of infectious diseases by using the best available evidence will contribute to better outcomes for stem cell transplant recipients, and provide the best possible “safety net” for these immunocompromised hosts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2242e1e9f62d3fd7b0b36245cb2c79fd https://doi.org/10.3390/jcm9030865 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.