Clinical features of hepatitis B and C virus infections, with high α-fetoprotein levels but not hepatocellular carcinoma
| Autor: | Woon Tae Jung, Bo Ra Kim, Wan Soo Kim, Jae Min Lee, Dae Hong Jeon, Hyun Chin Cho, Hyun Jin Kim, Ok Jae Lee, Jin Joo Kim, Chang Min Lee, Chang Yoon Ha, Tae Hyo Kim, Hong Jun Kim, Sang Soo Lee, Cha Young Kim |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Observational Study medicine.disease_cause Antiviral Agents Gastroenterology Virus 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Internal medicine medicine Humans chronic hepatitis C chronic hepatitis B Clinical significance neoplasms Retrospective Studies Hepatitis B virus business.industry Hazard ratio Retrospective cohort study hepatocellular carcinoma General Medicine Hepatitis C Hepatitis C Chronic Middle Aged Hepatitis B medicine.disease digestive system diseases α-fetoprotein 030220 oncology & carcinogenesis Hepatocellular carcinoma Immunology ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female 030211 gastroenterology & hepatology alpha-Fetoproteins business Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000005844 |
| Popis: | Supplemental Digital Content is available in the text The appropriate α-fetoprotein (AFP) level to confirm hepatocellular carcinoma (HCC) could be 100 ng/mL; however, the clinical significance of falsely elevated AFP in patients without HCC has not been fully studied. We investigated the clinical features and outcome of patients without HCC but with high AFP levels (100 ng/mL), especially with chronic hepatitis B (CHB) or C (CHC). The sample included 124 consecutive patients with CHB (n = 97) or CHC (n = 27), with AFP levels >100 ng/mL and without HCC at baseline. Multivariate Cox proportional regression analysis was performed to determine the factors associated with AFP normalization and HCC development. During the mean 52-month follow-up, the proportion of patients with CHB with AFP normalization (90.7%) was significantly higher than the proportion of patients with CHC (59.3%, P 100 ng/mL). With either CHB or CHC, persistent AFP elevation (>12 months), regardless of antiviral treatment, might be an important marker of HCC development. |
| Databáze: | OpenAIRE |
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