Green tea and bilberry protective effect against gentamicin-induced nephrotoxicity in rats
| Autor: | Dušan Sokolović, Milica Veljković, Dragana R. Pavlović, Ivan Ilic |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant Bilberry green tea medicine.medical_treatment bilberry gentamicin Pharmacology 030226 pharmacology & pharmacy Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine rat Saline Creatinine Kidney business.industry nephrotoxicity 030111 toxicology food and beverages General Medicine 3. Good health medicine.anatomical_structure chemistry Urea Gentamicin business medicine.drug |
| Zdroj: | Acta Facultatis Medicae Naissensis (2020) 37(3):261-266 |
| ISSN: | 2217-2521 0351-6083 |
| Popis: | The aim of our study was to investigate if green tea and bilberry have protective effect on gentamicin-induced kidney damage, when applied together, and to make a connection between their effects. GM group of rats received only gentamicin, GT group received green tea only, B group received only bilberry, whereas control (C) group received saline only. GT+GM group received green tea together with gentamicin, and B+GM group received bilberry together with gentamicin. Biochemical analysis showed significantly increased urea and creatinine levels in GM group when compared to groups that also received bilberry or green tea. Histological analysis showed complete disruption of glomerular basal membrane as well as basal membranes of both proximal and distal tubules in GM group. These destructive effects were significantly milder and limited only to proximal tubules when bilberry or green tea was applied simultaneously with gentamicin. Both green tea and bilberry protective effect on gentamicin-induced nephrotoxicity is manifested because of their strong antioxidant activity. Since they are strong antioxidants, widely distributed in nature, they can offer available and inexpensive adjuvant therapy in Gram-negative infections, which can relieve gentamicin nephrotoxicity, but will not affect its bactericidal effect. |
| Databáze: | OpenAIRE |
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