Physiological and Molecular Dissection of Daily Variance in Exercise Capacity
| Autor: | Saar Ezagouri, Ziv Zwighaft, Gad Asher, Stéphane Doutreleau, Samuel Verges, Marina Golik, Jonathan Sobel, Benjamin Ladeuix, Sébastien Baillieul |
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| Přispěvatelé: | Weizmann Institute of Science [Rehovot, Israël], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), SALAS, Danielle |
| Rok vydání: | 2019 |
| Předmět: |
circadian rhythm
0301 basic medicine medicine.medical_specialty clocks Physiology [SDV]Life Sciences [q-bio] Circadian clock AICAR Biology transcriptomics 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Glycolysis Circadian rhythm skeletal muscle Molecular Biology Beta oxidation exercise AMPK Skeletal muscle Cell Biology metabolomics mitochondria [SDV] Life Sciences [q-bio] ZMP 030104 developmental biology medicine.anatomical_structure Endocrinology Exercise intensity metabolism 030217 neurology & neurosurgery PER1 |
| Zdroj: | Cell Metabolism Cell Metabolism, 2019, 30 (1), pp.78-91.e4. ⟨10.1016/j.cmet.2019.03.012⟩ |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2019.03.012 |
| Popis: | International audience; Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput gene expression and metabolic profiling of skeletal muscle revealed metabolic pathways that are differently activated upon exercise in a daytime-dependent manner. Remarkably, we discovered that ZMP, an endogenous AMPK activator, is induced by exercise in a time-dependent manner to regulate key steps in glycolytic and fatty acid oxidation pathways and potentially enhance exercise capacity. Overall, we propose that time of day is a major modifier of exercise capacity and associated metabolic pathways. |
| Databáze: | OpenAIRE |
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