The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development

Autor: Lemei Zheng, Mengna Li, Jianxia Wei, Shipeng Chen, Changning Xue, Yuting Zhan, Yumei Duan, Hongyu Deng, Wei Xiong, Guiyuan Li, Ming Zhou
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cellular Physiology. 237:2758-2769
ISSN: 1097-4652
0021-9541
DOI: 10.1002/jcp.30733
Popis: N6-methyladenosine (m6A) is an extremely common and conservative posttranscriptional modification, that can specifically target and regulate the expression or stability of a series of tumor-related genes, thus playing critical roles in the occurrence and development of tumors. c-Myc is an important tumorigenic transcription factor that promotes tumorigenesis and development by mainly regulating the expression of downstream target genes. Increasing evidence shows that m6A modification, as well as abnormal expression and regulation of c-Myc, is critical molecular mechanisms driving tumorigenesis and development. Although more evidence has been uncovered about the individual roles of m6A modification or c-Myc in tumors, the interaction between m6A modification and c-Myc in tumorigenesis and development has not been systematically summarized. Therefore, this review is focused on the mutual regulation between m6A modification and c-Myc expression and stability as well as its roles in tumorigenesis and development. We also summarized the potential value of the interaction between m6A modification and m6A expression and stability in tumor diagnosis and treatment, which provides a specific reference for revealing the mechanism of tumor occurrence and development as well as clinical diagnosis and treatment.
Databáze: OpenAIRE
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