Inhibition of Exaggerated Gastrointestinal Glucagon Responses in Chronic Pancreatitis by Somatostatin
Autor: | P. T. Child, A. I. Vinik, W. P. U. Jackson, J. L. Botha |
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Rok vydání: | 1977 |
Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Microgram medicine.medical_treatment Clinical Biochemistry Biochemistry Glucagon Endocrinology Internal medicine medicine Humans Insulin In patient Aged Glucose tolerance test medicine.diagnostic_test business.industry Biochemistry (medical) Glucose Tolerance Test Middle Aged medicine.disease Control subjects Somatostatin Pancreatitis Chronic Disease business |
Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 45:1265-1270 |
ISSN: | 1945-7197 0021-972X |
DOI: | 10.1210/jcem-45-6-1265 |
Popis: | Oral glucose administration caused an exaggerated release of cross-reacting gastrointestinal glucagon-like immunoreactivity (GLI) and a slight early rise in immunoreactive glucagon (IRG) concentration in patients with chronic pancreatitis, who have impaired insulin release. Intravenous administration of 200 microgram of somatostatin, followed by infusion of 200 microgram over 2 1/2 h, abolished the GLI and insulin responses, but did not change glucose tolerance. This contrasts with the relatively minor effects of somatostatin on GLI responses in control subjects where the clear deterioration in glucose tolerance may relate to inhibition of insulin release. |
Databáze: | OpenAIRE |
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