DARK ADAPTATION IN MACULAR TELANGIECTASIA TYPE 2
| Autor: | Tjebo F. C. Heeren, Philipp Herrmann, Kristina Hess, Clarissa Mai, Jennifer Nadal, Frank G. Holz, Simone Tzaridis, Peter Charbel Issa |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Visual Acuity Dark Adaptation Adaptation (eye) Recovery rate Optical coherence tomography Retinal Rod Photoreceptor Cells Foveal Ophthalmology medicine Macular Pigment Humans In patient Prospective Studies Aged Macular telangiectasia medicine.diagnostic_test business.industry Parafovea General Medicine Middle Aged medicine.disease Cross-Sectional Studies Retinal Cone Photoreceptor Cells Female Telangiectasia Hereditary Hemorrhagic sense organs business Tomography Optical Coherence |
| Zdroj: | Retina. 40:2018-2025 |
| ISSN: | 0275-004X |
| Popis: | PURPOSE To evaluate dark adaptation (DA) in patients with macular telangiectasia Type 2 (MacTel). METHODS After a local photobleach (4 × 4° size, 83% bleach), DA was measured using a test stimulus (2° diameter) projected at 5° eccentricity horizontal from the foveal center within the temporal parafovea. Cone plateau, rod intercept time, and rod recovery rate (S2) were calculated from the resulting DA curves. Findings were correlated with disease stages (according to Gass and Blodi), the area of ellipsoid zone loss in optical coherence tomography, and macular pigment loss ("MP-Classes 1-3"). RESULTS Fifty-nine eyes of 59 patients were compared with 18 eyes of 18 healthy controls. Dark adaptation was significantly impaired in patients with MacTel. Although differences were most pronounced for parameters indicating rod-mediated recovery, cone-mediated recovery was also decreased, yet to a lesser extent. Dark adaptation parameters were only weakly associated with disease stages and ellipsoid zone loss. A better association was found between rod-mediated recovery (S2 and rod intercept time) and macular pigment loss (Kendall's tau for rod intercept time: 0.69 and S2: -0.51; both P < 0.0001). CONCLUSION Dark adaptation is significantly impaired in patients with MacTel. Our results indicate an association of reduced macular pigment and rod dysfunction in MacTel. |
| Databáze: | OpenAIRE |
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