Quantile-based fecal hemoglobin concentration for assessing colorectal neoplasms with 1,263,717 Taiwanese screenees
| Autor: | Yi-Chia Lee, Hsiao Hsuan Jen, Sherry Yueh Hsia Chiu, Han-Mo Chiu, Jean Ching Yuan Fann, Szu Min Peng, Hsiu Hsi Chen, Chen Yang Hsu, Sam Li Sheng Chen, Amy Ming Fang Yen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adenoma
Male Percentile medicine.medical_specialty 020205 medical informatics Colorectal cancer Taiwan Health Informatics 02 engineering and technology lcsh:Computer applications to medicine. Medical informatics Gastroenterology Cohort Studies 03 medical and health sciences Feces Hemoglobins 0302 clinical medicine Bayesian inversion Predictive Value of Tests Internal medicine 0202 electrical engineering electronic engineering information engineering medicine Fecal hemoglobin Humans 030212 general & internal medicine Early Detection of Cancer Aged business.industry Health Policy Bayes Theorem Colonoscopy Middle Aged medicine.disease Computer Science Applications Occult Blood Cohort Screening lcsh:R858-859.7 Female Hemoglobin business Colorectal Neoplasms Quantile Research Article |
| Zdroj: | BMC Medical Informatics and Decision Making BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-10 (2019) |
| ISSN: | 1472-6947 |
| Popis: | Background Although fecal hemoglobin concentration (f-Hb) was highly associated with the risk of colorectal neoplasms, current studies on this subject are hampered by skewedness of the data and the ordinal property of f-Hb has not been well studied yet. Our aim was to develop a quantile-based method to estimate adjusted percentiles (median) of fecal hemoglobin concentration and their derived prediction for the risk of multistage outcomes of colorectal disease. Methods We used a 6-year follow-up cohort of Taiwanese nationwide colorectal screening program with fecal immunochemical testing (FIT) to obtain fecal hemoglobin concentration and applied accelerated failure time multi-variable analyses to make the comparison of adjusted median and other percentitles of fecal hemoglobin across four categories of colorectal carcinogenesis. We then predicted the risk of colorectal neoplasms on the basis of the corresponding percentile values by using accelerated failure time model with Bayesian inversion method. Results The adjusted median fecal hemoglobin concentration of nonadvanced adenoma, advanced adenoma, and colorectal cancer were 57, 82, and 163 μg/g feces as opposed to 0 μg/g feces for the normal group. At 90 μg/g of f-Hb, the highly suspected cut-off for colorectal disease, the risks were 17% for non-advanced adenoma, 6% for advanced adenoma, and 9% for CRC. Life-time risks of each colorectal neoplasm were derived by percentiles of fecal hemoglobin concentration. Conclusion Covariate-adjusted risk stratification for multistage outcomes of colorectal neoplasia were provided by using the quantiles of fecal hemoglobin concentration, yielding the estimated life-time risks of 25th to 75th quantitles, ranging from 0.5 to 44% for colorectal cancer, 0.2 to 46% for non-advanced adenoma, and 0.1 to 20% for advanced adenoma. Electronic supplementary material The online version of this article (10.1186/s12911-019-0812-1) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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