Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis
| Autor: | Filippo Maria Ubaldi, Alberto Vaiarelli, Fulvio Zullo, Danilo Cimadomo, Roberta Venturella, Carlo Alviggi, Silvia Picarelli, Alessandro Conforti, Laura Rienzi, Luigi Carbone, Antonio La Marca |
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| Přispěvatelé: | Conforti, A., Picarelli, S., Carbone, L., La Marca, A., Venturella, R., Vaiarelli, A., Cimadomo, D., Zullo, F., Rienzi, L., Ubaldi, F. M., Alviggi, C. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Fresh cycle Cryopreserved cycle 03 medical and health sciences 0302 clinical medicine ART Blastocyst Cryopreserved cycles Fresh cycles Perinatal outcome Pregnancy medicine Humans reproductive and urinary physiology Cryopreservation 030219 obstetrics & reproductive medicine Singleton Obstetrics business.industry Blastocyst Transfer Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Odds ratio Infant Low Birth Weight Delivery Obstetric Confidence interval Embryo transfer 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Meta-analysis embryonic structures Female business Infant Premature Developmental Biology |
| Popis: | The transfer of cryopreserved blastocysts is increasing in IVF centres. However, little is known about the perinatal and obstetric outcomes of this procedure. In an attempt to further elucidate these issues, a systematic review and meta-analysis was conducted to compare cryopreserved transfer with fresh blastocyst embryo transfer. The results show that the risk of both preterm (odds ratio [OR] 0.89, 95% confidence interval [CI] 0.80–0.99, P = 0.04) and low birthweight births (OR 0.82, 95% CI 0.68–0.99, P = 0.04) was significantly lower after cryopreserved blastocyst transfer than after fresh blastocyst transfer. The rate of large for gestational age births was significantly higher (OR 1.68, 95% CI 1.55–1.82, P < 0.00001) and the rate of small for gestational age births significantly lower (OR 0.59, 95% CI 0.54–0.65, P < 0.00001) after cryopreserved blastocyst transfer. The transfer of cryopreserved blastocysts was associated with a significantly lower risk of placental abruption (OR 0.58, 95% CI 0.40–0.83, P = 0.003) but a significantly higher risk of Caesarean section (OR 1.21, 95% CI 1.01–1.43, P = 0.03). In conclusion, the perinatal and obstetric outcomes associated with the transfer of cryopreserved blastocysts differ from those associated with fresh blastocyst transfer. |
| Databáze: | OpenAIRE |
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