Serum leptin concentration can predict cardiovascular outcomes and all-cause death in maintenance hemodialysis patients
| Autor: | Qinbo Yang, Mei Yang, Mei Han, Baihai Su, Ruoxi Liao, Zheng Qin, Yuqin Xiong |
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| Rok vydání: | 2021 |
| Předmět: |
Leptin
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Left ventricular hypertrophy Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine medicine Humans Prospective Studies Risk factor Prospective cohort study business.industry Vascular disease Medical record Biochemistry (medical) General Medicine medicine.disease Peripheral 030104 developmental biology Cardiovascular Diseases 030220 oncology & carcinogenesis Kidney Failure Chronic Hypertrophy Left Ventricular Hemodialysis business |
| Zdroj: | Clinica Chimica Acta. 520:87-94 |
| ISSN: | 0009-8981 |
| Popis: | BACKGROUND We explored the associations between serum leptin concentration and cardiovascular prognosis in maintenance hemodialysis patients. METHODS In our prospective study with no intervention, demographics data at baseline were collected from electronic medical records. Serum leptin concentration was determined by ELISA. Patients underwent body composition assessment and echocardiographic measurements after hemodialysis. The primary endpoints were defined as cardiovascular events (CVEs), cardiovascular death (CVD) and all-cause death. RESULTS A total of 165 eligible patients aged 51(43-65) y were enrolled and the mean serum leptin concentration was 35.49 (29.98) ng/ml. During a median follow-up of 18 (12-22) months, CVEs occurred in 37 (22.42%) patients and the cardiovascular and all-cause mortality was 10.91% and 21.82%. Serum leptin concentration was associated with CVEs (HR = 0.982, p = 0.003), CVD (HR = 0.934, p = 0.002) and all-cause death (HR = 0.943, p |
| Databáze: | OpenAIRE |
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