Ultrastructural studies of myonecrosis induced by cobra venom in mice
| Autor: | Anthony T. Tu, John M. Stringer, Robert A. Kainer |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Pathology
medicine.medical_specialty Myofilament Necrosis Venom Cobra Vacuole Biology Endoplasmic Reticulum Toxicology complex mixtures Mice Muscular Diseases medicine Animals Envenomation computer.programming_language Pharmacology Venoms Muscles Skeletal muscle Snakes Anatomy Mitochondria Muscle Microscopy Electron medicine.anatomical_structure Ultrastructure medicine.symptom Mitochondrial Swelling computer |
| Zdroj: | Toxicology and Applied Pharmacology. 18:442-450 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(71)90136-0 |
| Popis: | The fine structure of necrotic skeletal muscle in mice injected im with venom of the cobra (Naja naja kaouthia) was studied. Degeneration of the entire muscle fiber and its constituents was observed. The myofilaments coalesced to form an amorphous mass, and the sarcotubular system disappeared. The mitochondria swelled into vacuoles containing fragmented cristae. The vacuoles ruptured and were lysed. The degenerated fibre became a less electron-dense mass containing a few cellular remnants enclosed by a vestige of the plasma membrane. Envenomation with cobra venom does cause necrosis of skeletal muscle in mice. |
| Databáze: | OpenAIRE |
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