Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats
| Autor: | L.A. Ruocco, Giampiero Boatto, Walter Adriani, Angela Tino, Maria Nieddu, Marcello Leopoldo, Luisa Minghetti, Giovanni Laviola, Enza Lacivita, Maria Antonietta Ajmone-Cat, Francesca Passarelli, Paola Nativio, Emilia Romano, Adolfo G. Sadile |
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| Přispěvatelé: | Romano, E., Ruocco, L. A., Nativo, P., Lacivita, E. . Ajmone Cat M. A., Boatto, G., Nieddu, M., Tino, A., Sadile, Adolfo, Passarelli, F., Leopoldo, M., Laviola, G., Adriani, W. |
| Rok vydání: | 2014 |
| Předmět: |
Agonist
medicine.medical_specialty Time Factors medicine.drug_class glutamate Stimulation Striatum immunohistochemisty Piperazines Mice Dopamine receptor D2 Internal medicine medicine Animals 5-HT receptor Dopamine transporter Serotonin Plasma Membrane Transport Proteins Behavior Animal biology Receptors Dopamine D2 SERT General Neuroscience Ventral striatum Dopaminergic Brain DAT Circadian Rhythm Rats Serotonin Receptor Agonists Endocrinology medicine.anatomical_structure Receptors Serotonin biology.protein sleep wake circadian cycle Psychology emotional/cognitive modulations |
| Zdroj: | Reviews in the neurosciences 25 (2014): 383–400. doi:10.1515/revneuro-2014-0007 info:cnr-pdr/source/autori:Romano, Emilia; Ruocco, Lucia A.; Nativio, Paola; Lacivita, Enza; Ajmone-Cat, Maria A.; Boatto, Giampiero; Nieddu, Maria; Tino, Angela; Sadile, Adolfo G.; Minghetti, Luisa; Passarelli, Francesca; Leopoldo, Marcello; Laviola, Giovanni; Adriani, Walter/titolo:Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats/doi:10.1515%2Frevneuro-2014-0007/rivista:Reviews in the neurosciences/anno:2014/pagina_da:383/pagina_a:400/intervallo_pagine:383–400/volume:25 |
| ISSN: | 2191-0200 0334-1763 |
| DOI: | 10.1515/revneuro-2014-0007 |
| Popis: | The serotonin receptor 7 (5-HT7-R), is very abundant in the thalamus, hypothalamus, dorsal raphe nucleus and hippocampus; at lower levels it is found also in the cortex, striatum and amygdala. This neurochemical receptor system plays important functional roles in learning and memory, in regulation of mood and circadian rhythmicity. Recently, many agonist drugs selective for this receptor have been developed and their effects reported. Presently, we review some recent studies we have conducted aimed to evaluate the modulatory effect of a subchronic regimen with LP-211, a new selective agonist compound belonging to 1-arylpiperazine category, on behavioural and molecular parameters. At low dose (0.25 mg/kg, i.p.), LP-211 induced in adult mice a six-hour anticipated wake up with no temporal landmark (constant light) acting as non-photic stimulus for “internal clock” resetting. In standard 12:12h L/D cycle, we observed a subchronic effect (5-6 days at 0.25 mg/kg, once/day), on delay of wake up associated with a reduction of peak locomotor activity and any evidence for a real cellular proliferation after ex vivo analysis. The other studies, conduct on rats, were aimed to investigate long-term effects of subchronic LP-211 administration into adulthood development. Subchronic LP-211 (0.125 mg/kg, i.p. once/day) during the prepuberal phase reduced L-Glutamate, NMDAR1 and DAT, within the ventral striatum. Moreover, we observed a clear reduction of the immunoreactivity of serotonin transporter (SERT) and dopaminergic D2 receptors at dorsal striatum. These results represent a starting point to explore the neurophysiology of 5-HT7-R: subchronic LP-211 in rats and mice appears a suitable tool for studying the role of 5-HT7-R in sleep disorders, emotional and motivational regulations, attentive processes and executive functions. |
| Databáze: | OpenAIRE |
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