Effects of HOE 140 on Some Renal Functions in Type I Diabetic Mice
| Autor: | M Navarro, O. L. Catanzaro, Adriana Zuccollo, A Dominguez, G M Prendes |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Physiology Urinary system Peptide hormone Biology Bradykinin Kidney Function Tests Diabetes Mellitus Experimental Mice Physiology (medical) Internal medicine Diabetes mellitus medicine Animals Diabetic Nephropathies Receptor Bradykinin Receptor Antagonists Analysis of Variance Antagonist General Medicine Kallikrein Kinin Streptozotocin medicine.disease Mice Inbred C57BL Endocrinology medicine.drug |
| Zdroj: | Archives of Physiology and Biochemistry. 104:252-254 |
| ISSN: | 1744-4160 1381-3455 |
| DOI: | 10.1076/apab.104.2.252.12890 |
| Popis: | To investigate in mice the mechanisms underlying renal functions in a type I diabetes model, we have suppressed B2 kinin receptors local activities by their specific antagonist D-Arg [Hyp3-Thi5-D-Tic7-Oic8]BK (HOE 140). Mice made diabetic with low consecutive doses of streptozotocin (STZ) (45 mg/k BW during 5 days) were injected with HOE 140 (15 micrograms/twice a day) for 15 days. This drug did not modify glycemia of STZ treated animals but a significantly reduction of urinary proteins, nitrites and kallikrein was observed. These results indicate that kinin B2-receptors activation is implicated in the alterations of renal function in this model of type I diabetes in mice. |
| Databáze: | OpenAIRE |
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