Assessment of brain age in posttraumatic stress disorder : findings from the ENIGMA PTSD and brain age working groups

Autor: Ashley N. Clausen, Kelene A. Fercho, Molly Monsour, Seth Disner, Lauren Salminen, Courtney C. Haswell, Emily Clarke Rubright, Amanda A. Watts, M. Nicole Buckley, Adi Maron‐Katz, Anika Sierk, Antje Manthey, Benjamin Suarez‐Jimenez, Bunmi O. Olatunji, Christopher L. Averill, David Hofmann, Dick J. Veltman, Elizabeth A. Olson, Gen Li, Gina L. Forster, Henrik Walter, Jacklynn Fitzgerald, Jean Théberge, Jeffrey S. Simons, Jessica A. Bomyea, Jessie L. Frijling, John H. Krystal, Justin T. Baker, K. Luan Phan, Kerry Ressler, Laura K. M. Han, Laura Nawijn, Lauren A. M. Lebois, Lianne Schmaal, Maria Densmore, Martha E. Shenton, Mirjam Zuiden, Murray Stein, Negar Fani, Raluca M. Simons, Richard W. J. Neufeld, Ruth Lanius, Sanne Rooij, Saskia B.J. Koch, Serena Bonomo, Tanja Jovanovic, Terri deRoon‐Cassini, Timothy D. Ely, Vincent A. Magnotta, Xiaofu He, Chadi G. Abdallah, Amit Etkin, Christian Schmahl, Christine Larson, Isabelle M. Rosso, Jennifer Urbano Blackford, Jennifer S. Stevens, Judith K. Daniels, Julia Herzog, Milissa L. Kaufman, Miranda Olff, Richard J. Davidson, Scott R. Sponheim, Sven C. Mueller, Thomas Straube, Xi Zhu, Yuval Neria, Lee A. Baugh, James H. Cole, Paul M. Thompson, Rajendra A. Morey
Přispěvatelé: Adult Psychiatry, APH - Mental Health, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Global Health, Clinical Psychology and Experimental Psychopathology, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BRAIN AND BEHAVIOR
Brain and behavior. John Wiley and Sons Inc.
Neuroscience Institute Publications
Clausen, A N, Fercho, K A, Monsour, M, Disner, S, Salminen, L, Haswell, C C, Rubright, E C, Watts, A A, Buckley, M N, Maron-Katz, A, Sierk, A, Manthey, A, Suarez-Jimenez, B, Olatunji, B O, Averill, C L, Hofmann, D, Veltman, D J, Olson, E A, Li, G, Forster, G L, Walter, H, Fitzgerald, J, Théberge, J, Simons, J S, Bomyea, J A, Frijling, J L, Krystal, J H, Baker, J T, Phan, K L, Ressler, K, Han, L K M, Nawijn, L, Lebois, L A M, Schmaal, L, Densmore, M, Shenton, M E, van Zuiden, M, Stein, M, Fani, N, Simons, R M, Neufeld, R W J, Lanius, R, van Rooij, S, Koch, S B J, Bonomo, S, Jovanovic, T, deRoon-Cassini, T, Ely, T D, Magnotta, V A, He, X, Abdallah, C G, Etkin, A, Schmahl, C, Larson, C, Rosso, I M, Blackford, J U, Stevens, J S, Daniels, J K, Herzog, J, Kaufman, M L, Olff, M, Davidson, R J, Sponheim, S R, Mueller, S C, Straube, T, Zhu, X, Neria, Y, Baugh, L A, Cole, J H, Thompson, P M & Morey, R A 2021, ' Assessment of brain age in posttraumatic stress disorder : Findings from the ENIGMA PTSD and brain age working groups ', Brain and Behavior . https://doi.org/10.1002/brb3.2413
Brain and Behavior, 12(1):e2413. Wiley-Blackwell
Brain and Behavior
Brain and Behavior, Vol 12, Iss 1, Pp n/a-n/a (2022)
Brain and Behavior. John Wiley and Sons Inc.
ISSN: 2162-3279
2157-9032
Popis: Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.
Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. We explored estimates of brain age, as compared to chronological age, as a possible marker of accelerated aging in PTSD populations leveraging a large multi‐site sample. We identified an interaction of PTSD, age, and sex which showed young males with PTSD had a greater brain predicted age difference [PAD] than young male controls, young females with PTSD, and young females without PTSD. A similar pattern was present in middle‐aged males, but the effect of PTSD was weaker than in young adults. Male controls in the old subgroup exhibited higher brain‐PAD than old males with PTSD, old females with PTSD, and old females without PTSD.
Databáze: OpenAIRE
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