Gender-sex differences in autoimmune atrophic gastritis
| Autor: | Edith Lahner, Emanuele Dilaghi, Sophia Cingolani, Giulia Pivetta, Ludovica Dottori, Gianluca Esposito, Ilaria Marzinotto, Vito Lampasona, Raffaella Buzzetti, Bruno Annibale |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Gastritis
Atrophic Male Sex Characteristics Biochemistry (medical) autoimmunity Public Health Environmental and Occupational Health Anemia General Medicine Autoimmune Diseases Cross-Sectional Studies Physiology (medical) atrophic gastritis autoimmune atrophic gastritis gender Humans Female Atrophy Dyspepsia Autoantibodies HLA-DRB1 Chains |
| Popis: | Gender-sex differences in autoimmune diseases are gaining increasing attention due to their effects on prevalence and clinical features. Data on gender-sex differences in autoimmune atrophic gastritis (AAG), a chronic not-self-limiting inflammatory condition characterized by corpus-oxyntic mucosa atrophy sparing the antrum, are lacking. This study aimed to assess possible gender-sex differences of clinical, serological, histological, and genetic features in AAG patients. Cross-sectional study on 435 patients with histological-AAG, stratified according to female-male gender. In subsets of patients, serum gastric-autoantibodies against intrinsic-factor (IFA) and parietal-cells (PCA) by luminescent-immunoprecipitation-system (LIPS) (n = 81) and of HLA-DRB1-genotyping (n = 89) were available and stratified according to sex. Female AAG-patients were preponderant: 69.2%vs30.8%, P0.0001(ratio 2.2:1). Females were more frequently PCA and/or IFA-positive than males (90.9%vs73.1%, P = 0.0361). HLA-DRB1*06-alleles were significantly more frequent in females [30%vs4%, P = 0.01, OR 10.1(95%CI 1.3-80.4); HLA-DRB1*04-alleles were more frequent and HLA-DRB1*03 and *05-alleles less frequent in females without reaching statistical significance. At logistic regression, iron-deficiency-anemia [OR 3.6(95%CI 1.9-7.0)], body-mass-index25m |
| Databáze: | OpenAIRE |
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