Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways
| Autor: | Wanhong Jiang, James Lyon, Ray V. Rajotte, Kenneth Cardona, Zvonimir Milas, Elizabeth Strobert, J. Cano, Collin J. Weber, Christian P. Larsen, Gregory S. Korbutt, Shivaprakash Gangappa, Brad V Hacquoil, Hameeda Bello-Laborn, Thomas C. Pearson |
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| Rok vydání: | 2005 |
| Předmět: |
Graft Rejection
endocrine system Time Factors Swine Transplantation Heterologous Cell- and Tissue-Based Therapy Islets of Langerhans Transplantation General Biochemistry Genetics and Molecular Biology Islets of Langerhans Pancreatectomy Long term survival Medicine Animals geography geography.geographical_feature_category Porcine endogenous retrovirus business.industry Porcine islets Graft Survival General Medicine Islet Transplantation Regimen Animals Newborn Immunology Macaca business Insulin independence Median survival |
| Zdroj: | Nature medicine. 12(3) |
| ISSN: | 1078-8956 |
| Popis: | We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation. |
| Databáze: | OpenAIRE |
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