Thyrotropin Receptor Expression in Cultured Graves' Orbital Preadipocyte Fibroblasts Is Stimulated by Thyrotropin
| Autor: | Werner Joba, Rebecca S. Bahn, Charyl M. Dutton, Armin E. Heufelder |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty genetic structures endocrine system diseases Endocrinology Diabetes and Metabolism Thyrotropin Adipose tissue Stimulation Thyrotropin receptor Endocrinology In vivo Internal medicine Adipocytes medicine Humans RNA Messenger Receptor Cells Cultured Messenger RNA Chemistry Stem Cells Receptors Thyrotropin Fibroblasts Immunohistochemistry Graves Disease eye diseases medicine.anatomical_structure hormones hormone substitutes and hormone antagonists Orbit (anatomy) |
| Zdroj: | Thyroid. 8:193-196 |
| ISSN: | 1557-9077 1050-7256 |
| DOI: | 10.1089/thy.1998.8.193 |
| Popis: | Our laboratory has shown recently that the thyrotropin receptor (TSHr) is expressed in orbital adipose/connective tissues from patients with Graves' ophthalmopathy (GO), and that this receptor is not demonstrable in orbital tissues from normal individuals. In order to study the regulation of TSHr expression in the orbit in GO, we treated cultures of Graves' orbital preadipocyte fibroblasts with the TSHr ligand thyrotropin (TSH; 100 mU/L). We found increased expression of both intact (2.4 kb) and variant (1.3 kb) TSHr mRNA and of TSHr protein in orbital fibroblasts following 72 hr treatment with TSH. These studies suggest that the expression of this receptor in the orbit in vivo may be stimulated by TSH or other TSHr ligands, and that this stimulation may be important in the development of GO. |
| Databáze: | OpenAIRE |
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