The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen
| Autor: | Pablo Engel, Jg, Gribben, Gj, Freeman, Lj, Zhou, Nozawa Y, Abe M, Lm, Nadler, Wakasa H, Tf, Tedder |
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| Rok vydání: | 1994 |
| Předmět: |
B-Lymphocytes
Membrane Glycoproteins Immunology Antibodies Monoclonal Fluorescent Antibody Technique Gene Expression Cell Biology Hematology CHO Cells Lymphocyte Activation Transfection Biochemistry Epitopes Antigens CD Cricetinae Immunoglobulin G B7-1 Antigen Leukocytes Mononuclear Animals Humans Tetradecanoylphorbol Acetate B7-2 Antigen Cell Division Muromonab-CD3 Thymidine |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0006-4971 |
| Popis: | T-cell activation is initiated after T-cell receptor binding to antigen, but also requires interactions between costimulatory molecules expressed on antigen-presenting cells. An important costimulatory molecule expressed by monocytes and activated B lymphocytes has been recently identified and termed B7–2 or B70. Independently, a new Cluster of Differentiation was defined in the Fifth International Leukocyte Differentiation Antigen Workshop as CD86, a molecule predominantly expressed by monocytes and activated B lymphocytes. In this study, the two monoclonal antibodies that defined CD86, FUN-1 and BU-63, were shown to bind to cDNA transfected cells expressing B7– 2/B70. The FUN-1 monoclonal antibody also completely blocked the costimulatory activity of B7–2/B70 in functional assays. Therefore, the serologically defined CD86 differentiation antigen is the B7–2/B70 molecule. |
| Databáze: | OpenAIRE |
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