β-adrenoceptor antagonists and nightmares: A pharmacoepidemiological–pharmacodynamic study
| Autor: | Jacques Hamard, Vanessa Rousseau, Agnès Sommet, François Montastruc, Jean-Louis Montastruc, Philippe Garcia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Beta-adrenergic blocking agent Drug-Related Side Effects and Adverse Reactions Databases Pharmaceutical business.industry Pharmacoepidemiology Adrenergic beta-Antagonists 030226 pharmacology & pharmacy World health Dreams β adrenoceptor Pharmacovigilance 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Pharmacodynamic Study Humans Medicine Pharmacology (medical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychopharmacology. 35:1441-1448 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Aim: To compare different β-adrenoceptor antagonists for the risk of reporting nightmare. Methods: The study involved two approaches: first, we investigated in VigiBase®, the World Health Organization Individual Case Safety Report (ICSR) database, the disproportionality between exposure to each β-adrenoceptor antagonists and reports of nightmares between 1967 and 2019. Second, in a pharmacoepidemiological–pharmacodynamic analysis, we assessed whether use of β-adrenoceptor antagonists with moderate and high lipid solubility or strong 5-HT1A affinity were associated with an increased risk of reporting nightmares. We conducted multivariate logistic regression to estimate reporting odds ratios (RORs) of nightmares compared to all other adverse drug reactions. Results: Of the 126,964 reports recorded with β-adrenoceptor antagonists, 1138 (0.9%) were nightmares. The highest risk of reporting a nightmare was found with exposure of pindolol (adjusted ROR 2.82, 95%CI, 2.19–3.61), metoprolol (1.89, 1.66–2.16), and alprenolol (1.77, 1.06–2.97). Compared to use of low lipid solubility β-adrenoceptor antagonists, use of moderate or high lipid solubility β-adrenoceptor antagonists were significantly more associated with nightmare reports (aROR moderate vs. low 1.72, 95%CI 1.47–2.00 and aROR high vs. low 1.84, 95%CI 1.53–2.22). Use of moderate or high 5-HT1A affinity of β-adrenoceptor antagonists was associated with an increased ROR of nightmares compared with low 5-HT1A affinity of β-adrenoceptor antagonists (aROR moderate vs. low 1.22, 95%CI 1.04–1.43 and aROR high vs. low 2.46, 95%CI 1.93–3.13). Conclusion: In our large pharmacovigilance study, nightmares are more frequently reported for pindolol and metoprolol, and among β-adrenoceptor antagonists with high lipid solubility and high 5-HT1A receptor affinity. |
| Databáze: | OpenAIRE |
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