A new point-of-care test for the rapid detection of urinary tract infections
Autor: | Ottavia Stalio, Valeria Ferrante, Paolo Visca, Rossella Marino, Lorena Silvestri, Flavia Cristofano, Salvatore Di Somma, Giovanni Antonini, Francesca Losito, Lorenza Murgia, Michela Orrù, Valentina Cellitti, Vincenzo Ziparo, Alyexandra Arienzo |
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Přispěvatelé: | Arienzo, Alyexandra, Cellitti, Valentina, Ferrante, Valeria, Losito, Francesca, Stalio, Ottavia, Murgia, Lorenza, Marino, Rossella, Cristofano, Flavia, Orrù, Michela, Visca, Paolo, Di Somma, Salvatore, Silvestri, Lorena, Ziparo, Vincenzo, Antonini, Giovanni |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Point-of-care testing Urinary system UTI 030106 microbiology Medical laboratory Early detection Urinalysis Sensitivity and Specificity Rapid detection POCT 03 medical and health sciences 0302 clinical medicine Medical microbiology Diagnosis medicine Humans Outpatient clinic 030212 general & internal medicine Aged Aged 80 and over Clinical Laboratory Techniques business.industry Reproducibility of Results General Medicine Middle Aged Clinical trial Infectious Diseases ROC Curve Point-of-Care Testing Urinary Tract Infections Emergency medicine Female Original Article business Infection Diagnosi |
Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
Popis: | Urinary tract infections (UTIs) are among the most common infections in all age groups. Fast and accurate diagnosis is essential to ensure a timely and effective therapy. Alongside with reference culture-based methods, several point-of-care tests (POCTs) for early detection of UTIs have been developed, but they have not been significantly implemented in current clinical practice. The Micro Biological Survey (MBS) POCT is a simple test developed by MBS Diagnostics Ltd. (London, UK) for the detection and management of UTIs. The present study has been undertaken to investigate the potentials and limits of the MBS POCT. A total of 349 patients were enrolled in two open-label, monocentric, non-interventional clinical trials in collaboration with an Emergency Medicine department and the outpatient clinic of two hospitals in Rome. Results of urine analysis using the MBS POCT were compared with those of the routine culture-based tests for UTI diagnosis performed by the hospital laboratory. The MBS POCT provided fast results revealing high bacterial count UTIs (≥ 105 CFU/ml) with 97% accuracy, 92% sensitivity, 100% specificity, 99% PPV, and 96% NPV within a 5-h analytical time threshold. Electronic supplementary material The online version of this article (10.1007/s10096-019-03728-3) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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