Frequency and Correlates of Subjective Memory Complaints in Parkinson’s Disease with and without Mild Cognitive Impairment: Data from the Parkinson’s Disease Cognitive Impairment Study
| Autor: | Alessandra Nicoletti, Mario Zappia, Vincenzo Restivo, Roberto Monastero, D. Recca, Roberta Baschi |
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| Přispěvatelé: | Roberta Baschi, Alessandra Nicoletti, Vincenzo Restivo, Deborah Recca, Mario Zappia, Roberto Monastero |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Parkinson's disease Disease Neuropsychological Tests Anxiety Logistic regression Executive Function 0302 clinical medicine Surveys and Questionnaires Attention Cognitive impairment Aged 80 and over General Neuroscience Neuropsychology Parkinson Disease General Medicine Middle Aged musculoskeletal system Psychiatry and Mental health Clinical Psychology Visual Perception cardiovascular system Settore MED/26 - Neurologia Female cognitive impairment disability motor impairment subjective complaints Neuroscience (all) Geriatrics and Gerontology Psychiatry and Mental Health medicine.symptom medicine.medical_specialty Statistics Nonparametric 03 medical and health sciences Internal medicine mental disorders medicine Humans Dementia Aged Retrospective Studies Subjective complaints Cognitive Impairment Parkinson’s Disease Disability Motor Impairment Anxiety Memory Disorders business.industry medicine.disease Cross-Sectional Studies 030104 developmental biology Etiology Cognition Disorders business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 63:1015-1024 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-171172 |
| Popis: | Subjective memory complaints (SMC) may represent the preclinical phase of mild cognitive impairment (MCI) due to Alzheimer's disease. Dementia/MCI have been described with a high prevalence in Parkinson's disease (PD), but whether SMC may predict the development of cognitive impairment has been barely explored. To evaluate the frequency and clinical correlates of isolated SMC (PD-SMC) or within the construct of MCI in subjects with PD, 147 PD patients from the PArkinson's disease COgnitive impairment Study (PACOS) were consecutively recruited for the study. This is a multicenter study involving two Movement Disorder Centers in south Italy. All subjects underwent comprehensive neuropsychological evaluation and PD-MCI was diagnosed according to Litvan's criteria. The Memory Assessment Clinics Questionnaire was used to assess SMC. Logistic regression analysis, adjusted for demographics and significant covariates, was used to evaluate clinical differences between groups. Forty-two (28.6%) individuals presented with PD without SMC and/or MCI (PDw), 40 (27,2%) with PD-SMC, 48 (32,6%) PD-SMC-MCI, and 17 (11,6%) PD-MCI without SMC (PD-MCI). When compared to PDw, PD-SMC was significantly associated with anxiety (OR = 3.93, 95% CI = 1.18-13.03), while PD-SMC-MCI related to motor progression (OR = 5.29, 95% CI = 1.12-24.86), and instrumental disability (OR = 6.98, 95% CI = 2.08-23.38). About 60% of patients showed SMC, in isolation or within the MCI frame. The role of SMC in PD seems to have a different etiology depending on the presence/absence of MCI. In particular, PD-SMC would represent a subjective reaction to the disease, while PD-SMC-MCI would depict motor progression and disability. |
| Databáze: | OpenAIRE |
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