Comparison of cardiorespiratory reflexes in NK1 receptor knockout, heterozygous and wild-type mice in vivo
| Autor: | SP Hunt, Julian F. R. Paton, James Butcher, C De Felipe, Andrew J.H. Smith |
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| Přispěvatelé: | British Heart Foundation, Royal Society (UK) |
| Rok vydání: | 1998 |
| Předmět: |
Male
Bradycardia Heterozygote medicine.medical_specialty Baroreceptor Physiology Pressoreceptors Biology Mice Neurokinin-1 Receptor Antagonists Piperidines Reference Values Internal medicine Reflex medicine Animals Lung Phenylephrine Mice Knockout Respiration General Neuroscience Solitary tract Heart Receptors Neurokinin-1 Chemoreceptor Cells Endocrinology Reflex bradycardia Knockout mouse cardiovascular system Female Neurology (clinical) medicine.symptom circulatory and respiratory physiology medicine.drug Phenylbiguanide |
| Zdroj: | Journal of the Autonomic Nervous System. 69:89-95 |
| ISSN: | 0165-1838 |
| DOI: | 10.1016/s0165-1838(98)00018-6 |
| Popis: | Neurokinin-1 receptors (NK1) are present within the nucleus of the solitary tract, a nucleus which plays a vital role in cardiovascular and respiratory homeostasis. We compared the efficacy of the baroreceptor and pulmonary chemoreflexes between NK1 knockout, heterozygous and wild-type urethane-anaesthetised mice. The magnitude of the baroreceptor reflex mediated bradycardia, induced by a phenylephrine induced pressor response, was significantly greater in NK1 knockout mice (P This work was funded by the British Heart Foundation and the Royal Society. J.W.B. holds a BHF PhD Studentship. |
| Databáze: | OpenAIRE |
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