Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata
| Autor: | Xiao-Nian Li, Pei-Ji Zhao, Cheng Zou, Yan-Mei Chen, Yin-He Yang |
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| Rok vydání: | 2015 |
| Předmět: |
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Molecular Spectrometry Mass Electrospray Ionization Antifungal Agents Magnetic Resonance Spectroscopy Stereochemistry Electrospray ionization Molecular Conformation Pharmaceutical Science Crystallography X-Ray Article Analytical Chemistry Botryosphaeria sp. P483 lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Endophytes Physical and Theoretical Chemistry X-ray crystallography biology Chemistry Antinematodal Agents Organic Chemistry antifungal activity Absolute configuration Huperzia Nuclear magnetic resonance spectroscopy Huperzia serrata Endophytic fungus biology.organism_classification tetranorlabdane diterpenoid Chemistry (miscellaneous) Saccharomycetales Molecular Medicine Fermentation Diterpenes nematicidal activity |
| Zdroj: | Molecules Volume 20 Issue 9 Pages 16924-16932 Molecules, Vol 20, Iss 9, Pp 16924-16932 (2015) |
| ISSN: | 1420-3049 |
| Popis: | Two new tetranorlabdane diterpenoids, named botryosphaerins G (1) and H (2), were isolated from the solid fermentation products of Botryosphaeria sp. P483 along with seven known tetranorlabdane diterpenes (3–9). Their structures were elucidated by extensive analysis, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Their absolute configuration was confirmed by single-crystal X-ray diffraction analyses using the anomalous scattering of Cu Kα radiation. All of the isolated compounds were tested for activity against phytopathogenic fungi and nematodes. Compounds 2 and 3 showed antifungal activity and compound 2 showed weak nematicidal activity. |
| Databáze: | OpenAIRE |
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