Cross-reactive antigens in the pathogenesis of onchocerciasis
| Autor: | Graham R. Wallace, R. Whiston, Vivienne Connor, N M McKechnie, G. Braun, S. Kläger, E. Kasp |
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| Rok vydání: | 1993 |
| Předmět: |
030231 tropical medicine
Helminthiasis Cross Reactions medicine.disease_cause Autoimmunity Autoimmune Diseases Pathogenesis 03 medical and health sciences 0302 clinical medicine Antigen Immunity 030225 pediatrics Onchocerciasis Ocular medicine Animals Onchocerca biology business.industry medicine.disease biology.organism_classification Onchocerca volvulus eye diseases Rats Infectious Diseases Self Tolerance Rats Inbred Lew Antigens Helminth Immunology Parasitology Onchocerciasis business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0003-4983 |
| Popis: | The ocular disease associated with infection with Onchocerca volvulus is unique in that there is a wealth of epidemiological evidence to support the casual nature of the association but there is little known about the pathogenic mechanisms involved. We have identified a 44,000 M(r) component of ocular tissues that shows immunological cross-reactivity with an O. volvulus antigen. This immunological cross-reactivity between parasite and a component of host tissues may underlie the development of ocular disease in onchocerciasis. Preliminary experiments indicate that it is possible to initiate ocular disease in susceptible rats using the recombinant parasite antigen. This should allow the development of a laboratory model of ocular onchocerciasis and further our understanding of the mechanisms by which an infective organism can produce an auto-immune-like disease in the host. |
| Databáze: | OpenAIRE |
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