Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Prognosis of Patients with Aortic Aneurysms
| Autor: | Dong Xu, Yongchang Liu, Xin Fang, Xiaohu Meng, Changpin Huang, Jianyun Long, Xuchao Cai, Xupin Xie |
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| Rok vydání: | 2021 |
| Předmět: |
aortic aneurysms
medicine.medical_specialty business.industry Proportional hazards model Hazard ratio International Journal of General Medicine Retrospective cohort study Red blood cell distribution width General Medicine MIMIC-III medicine.disease Logistic regression red blood cell distribution width–albumin ratio Aortic aneurysm Internal medicine Intensive care medicine Cardiology Risk factor business retrospective cohort study Original Research |
| Zdroj: | International Journal of General Medicine |
| ISSN: | 1178-7074 |
| DOI: | 10.2147/ijgm.s328035 |
| Popis: | Jianyun Long, Xupin Xie, Dong Xu, Changpin Huang, Yongchang Liu, Xiaohu Meng, Xuchao Cai, Xin Fang Department of Vascular Surgery, Affiliated Hangzhou First Peopleâs Hospital, ZheJiang University School of Medicine, Hangzhou, Zhejiang, 310014, Peopleâs Republic of ChinaCorrespondence: Xin FangDepartment of Vascular Surgery, Affiliated Hangzhou First Peopleâs Hospital, ZheJiang University School of Medicine Hangzhou, Zhejiang, 310014, Peopleâs Republic of ChinaTel +86 571-56005600Email hzfhfx@126.comObjective: Red blood cell distribution width (RDW) is a predictor of adverse outcomes in aortic aneurysms. Recent recommendations suggest that combining RDW with other biomarkers could yield better results. We, therefore, propose evaluating the biomarker of vascular aging, albumin with RDW to predict the risk of aortic aneurysms. This study aims to explore whether the combination of RDW with albumin can effectively predict the prognosis of aortic aneurysm patients.Methods: This retrospective cohort study was conducted among adults (age > 18) with aortic aneurysms in the Medical Information Mart for Intensive Care Database III V1.4 (MIMIC-III). RAR was measured according to the red blood cell distribution width and albumin. The primary outcome was the 30-day mortality rate, and the secondary outcome was the 90-day and one-year mortality rates. Estimation of hazard ratios (HR) was obtained from Cox regression models for all-cause mortality related to red cell distribution width-to-albumin ratio (RAR) values.Results: In total, 312 patients were involved, with an average age of 74.9 ± 10.9 years and an average RAR value of 5.4 ± 1.6 mL/g. In 30 days for all-cause mortality, the HR (95% CI) in the highest RAR group (> 5.8 mL/g) in tertiles was 2.54 (1.25, 5.14) in the unadjusted model, with a significant difference compared with the reference group (P < 0.05). After adjusting for race, gender and age, there was still a correlation (P < 0.05), and the HR (95% CI) was 2.51 (1.23, 5.10). Further adjustment of possible covariates showed similar correlation in model 3 (P < 0.05), and HR (95% CI) was 2.66 (1.17, 6.01). Multivariable logistic regression shows that RAR is an independent risk factor for the outcome of aortic aneurysms after adjusting the covariates. In the subgroup analysis, we analyzed the patientâs complications, and no significant interaction was observed.Conclusion: RAR is a risk factor for patients with aortic aneurysms. However, more in-depth research is warranted to further analyze and substantiate our findings on the role of RAR in aortic aneurysm patients.Keywords: red blood cell distribution widthâalbumin ratio, aortic aneurysms, retrospective cohort study, MIMIC-III |
| Databáze: | OpenAIRE |
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