Preservation of pancreatic beta cell function with pulsatile cardiopulmonary bypass
| Autor: | Naoya Funakoshi, Hideo Nagaoka, Fumio Murayama, Masazumi Watanabe, Motoaki Satoh, Ryuichi Innami |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Blood Glucose
Male Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment Pulsatile flow Beta-cell Function Glucagon law.invention Islets of Langerhans law Internal medicine medicine Cardiopulmonary bypass Open heart operation Humans Insulin Lactic Acid Cardiac Surgical Procedures Cardiopulmonary Bypass Intraoperative Care C-Peptide business.industry Middle Aged medicine.anatomical_structure Endocrinology Hyperglycemia Pulsatile Flow Lactates Female Surgery Cardiology and Cardiovascular Medicine Pancreas business Hormone |
| Zdroj: | The Annals of Thoracic Surgery. 48:798-802 |
| ISSN: | 0003-4975 |
| Popis: | Pancreatic islet cell function and tissue metabolism were studied during and after cardiopulmonary bypass in 38 patients undergoing an open heart operation. Twenty patients were operated on with pulsatile cardiopulmonary bypass (group I) and 18, with nonpulsatile cardiopulmonary bypass (group II). Hyperglycemia was observed during and early after operation in both groups. In group I during cardiopulmonary bypass, the immunoreactive insulin and c-peptide levels and the insulin to glucagon molar ratio increased significantly compared with the preoperative values, but in group II, these variables did not alter significantly. An hour postoperatively, the immunoreactive insulin (71 +/- 34 muIU/mL) and c-peptide (8.3 +/- 3.0 ng/mL) levels and the insulin to glucagon molar ratio (11.0 +/- 5.2) in group I were significantly higher than those in group II (immunoreactive insulin, 29 +/- 20 muIU/mL; c-peptide, 4.8 +/- 1.8 ng/mL; insulin to glucagon molar ratio, 3.4 +/- 2.6). The blood lactate level in group I (41 +/- 22 mg/dL) was significantly lower than that in group II (78 +/- 30 mg/dL) an hour postoperatively. In conclusion, pulsatile cardiopulmonary bypass is quite effective in preserving pancreatic beta cell function and tissue metabolism during and early after open heart procedures. |
| Databáze: | OpenAIRE |
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