Emerging roles of RNA modifications in genome integrity
| Autor: | Jae Jin Kim, Seo Yun Lee, Kyle M. Miller |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
DNA Repair
DNA damage DNA repair Computational biology Biology Biochemistry DNA-binding protein Genomic Instability 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Transcription (biology) Gene expression Genetics Humans Molecular Biology 030304 developmental biology chemistry.chemical_classification Review Paper 0303 health sciences Genome RNA General Medicine Enzyme chemistry 030217 neurology & neurosurgery DNA DNA Damage |
| Zdroj: | Brief Funct Genomics |
| ISSN: | 2041-2657 2041-2649 |
| DOI: | 10.1093/bfgp/elaa022 |
| Popis: | Post-translational modifications of proteins are well-established participants in DNA damage response (DDR) pathways, which function in the maintenance of genome integrity. Emerging evidence is starting to reveal the involvement of modifications on RNA in the DDR. RNA modifications are known regulators of gene expression but how and if they participate in DNA repair and genome maintenance has been poorly understood. Here, we review several studies that have now established RNA modifications as key components of DNA damage responses. RNA modifying enzymes and the binding proteins that recognize these modifications localize to and participate in the repair of UV-induced and DNA double-strand break lesions. RNA modifications have a profound effect on DNA–RNA hybrids (R-loops) at DNA damage sites, a structure known to be involved in DNA repair and genome stability. Given the importance of the DDR in suppressing mutations and human diseases such as neurodegeneration, immunodeficiencies, cancer and aging, RNA modification pathways may be involved in human diseases not solely through their roles in gene expression but also by their ability to impact DNA repair and genome stability. |
| Databáze: | OpenAIRE |
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