Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis
| Autor: | Serbulent Yigit, Akin Tekcan, Ayse Feyda Nursal, Mehmet Kemal Tümer, Nilufer Kuruca, Kaan Yerliyurt |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Genotype Turkey polymerase chain reaction Endocrinology Diabetes and Metabolism Minisatellite Repeats Recurrent aphthous stomatitis Polymorphism Single Nucleotide variable number tandem repeat Interleukin-1 Receptor Antagonist law.invention Pathogenesis Gene Frequency Recurrence law Humans Immunology and Allergy Medicine Aphthous stomatitis Genetic Predisposition to Disease Risk factor Allele frequency Genetic Association Studies Polymerase chain reaction business.industry Interleukin 1 Receptor Antagonist Protein Variable number tandem repeat Interleukin 1 receptor antagonist variant Case-Control Studies proinflammatory cytokines Immunology Female Stomatitis Aphthous business |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:139-144 |
| ISSN: | 1871-5303 |
| Popis: | Background/Aims: Recurrent aphthous stomatitis (RAS) is one of the common oral inflammatory diseases. As immunological and genetic factors have been held responsible for the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk. Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Results: No statistically significant difference was found in the genotype distributions and allele frequencies of IL-1Ra VNTR variant between RAS patients and healthy controls. Conclusion: Lack of association between IL-1Ra VNTR variant and RAS could indicate that IL-1Ra has no significant role in the pathophysiology of RAS. However, it still appears to be very worthwhile to continue to search for cytokine gene variants in order to predict the development of such disease. |
| Databáze: | OpenAIRE |
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