Postpartum Circulating Markers of Inflammation and the Systemic Acute-Phase Response After Early-Onset Preeclampsia
| Autor: | Bas B. van Rijn, Arie Franx, Steven V. Koenen, Jan H. Veerbeek, Hein W. Bruinse, Emiel D. Post Uiterweer, Johanna G. van der Bom, Ger T. Rijkers, Mark Roest |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Inflammation 030204 cardiovascular system & hematology Fibrinogen Research Support Preeclampsia preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Risk Factors Internal Medicine medicine Journal Article Humans acute-phase response Non-U.S. Gov't Acute-Phase Reaction Pregnancy 030219 obstetrics & reproductive medicine biology business.industry Research Support Non-U.S. Gov't C-reactive protein Postpartum Period Acute-phase protein medicine.disease vaccination Immunity Innate C-Reactive Protein toll-like receptors inflammation Immunology TLR4 biology.protein Cytokines Female pregnancy medicine.symptom business Postpartum period Biomarkers medicine.drug Follow-Up Studies |
| Zdroj: | Hypertension, 67(2), 404-414 Hypertension, 67(2), 404. Lippincott Williams and Wilkins |
| ISSN: | 0194-911X |
| Popis: | Preeclampsia is an inflammatory-mediated hypertensive disorder of pregnancy and seems to be an early indicator of increased cardiovascular risk, but mechanisms underlying this association are unclear. In this study, we identified levels of circulating inflammatory markers and dynamic changes in the systemic acute-phase response in 44 women with a history of severe early-onset preeclampsia, compared with 29 controls with only uneventful pregnancies at 1.5 to 3.5 years postpartum. Models used were in vivo seasonal influenza vaccination and in vitro whole-blood culture with T-cell stimulants and the toll-like receptor-4 ligand lipopolysaccharide. Outcome measures were C-reactive protein, interleukin-6 (IL-6), IL-18, fibrinogen, myeloperoxidase, and a panel of 13 cytokines representative of the innate and adaptive inflammatory response, in addition to established cardiovascular markers. The in vivo acute-phase response was higher for women with previous preeclampsia than that for controls without such a history, although only significant for C-reactive protein ( P =0.04). Preeclampsia was associated with higher IL-1β ( P P TLR4 gene variants, and the IL-18 response to vaccination. In conclusion, preeclampsia is associated with alterations in the inflammatory response postpartum mostly independent of other established cardiovascular risk markers. |
| Databáze: | OpenAIRE |
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