Differential effects of methotrexate and liposomally conjugated methotrexate in rat adjuvant-induced arthritis
| Autor: | Bryan D. Williams, Anwen Sian Williams, Jeremy Camilleri, Nick Amos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Drug
musculoskeletal diseases Male media_common.quotation_subject Immunology Arthritis Inflammation medicine Immunology and Allergy Animals heterocyclic compounds Dosing skin and connective tissue diseases media_common Autoimmune disease Drug Carriers Phagocytes business.industry Anti-Inflammatory Agents Non-Steroidal medicine.disease Arthritis Experimental Rats Methotrexate Rats Inbred Lew Rheumatoid arthritis Liposomes medicine.symptom Drug carrier business medicine.drug Research Article |
| Popis: | SUMMARYIn this study we evaluated the comparative efficacy of free and liposomally conjugated methotrexate on both disease indtiction and suppression of acute inflammation in rat adjuvant-induced arthritis. Rats were given either empty liposomes (E-LIPO), free methotrexate (MTX) or the liposomally conjugated methotrexate (MTX-LIPO) at a dose of 100/μg/day for 7 consecutive days by the intravenous route. When MTX treatment was initiated on the day of arthritis induction the drug suppressed bul did not abolish the development of joint inflammation. Free MTX had no significant anti-inliammatory effect upon an established arthritis when dosing was commenced on day 11 post-adjuvant induction. Conversely, MTX-LIPO did not affect the progression of the arthritis when dosing was started on day 0, but exerted a significant anti-inflammatory effect on an established arthritis. MTX-LIPO treatment was significantly less haematotoxic than free MTX. |
| Databáze: | OpenAIRE |
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