Massive Intracranial Bleeding Requiring Emergency Splenectomy in a Patient with CMV-Associated Thrombocytopenia
| Autor: | Dina Ben-Yehuda, Alexander Gural, Shlomo Pomeranz, Zvi Israel, Shmuel Gillis, Anna Gafanovich, Danna Wolf |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Splenectomy Refractory immune system diseases Betaherpesvirinae hemic and lymphatic diseases Physiology (medical) medicine Humans Platelet Emergency Treatment Cerebral Hemorrhage Purpura Thrombocytopenic Idiopathic biology Platelet Count Vascular disease business.industry Hematology Middle Aged medicine.disease biology.organism_classification Thrombocytopenic purpura Surgery Purpura Cytomegalovirus Infections medicine.symptom Complication business |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 28:250-255 |
| ISSN: | 1424-8840 1424-8832 |
| DOI: | 10.1159/000022439 |
| Popis: | We describe a previously healthy male patient, with severe immune thrombocytopenic purpura (ITP) following CMV infection which was refractory to steroids and intravenous immunoglobulin, who developed massive intracranial bleeding. Despite an extremely low platelet count (2×109/liter) which was refractory to platelet transfusions, successful emergency splenectomy was performed, with rapid resolution of the thrombocytopenia. Bleeding complications are extremely rare in viral-associated ITP. Emergency splenectomy should be considered in the presence of life-threatening bleeding when other modalities fail to produce a rise in the platelet count. Infection with CMV should be ruled out in cases of severe, treatment-resistant ITP. |
| Databáze: | OpenAIRE |
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