Are we satisfied with the tools for the diagnosis of gonococcal infection in females?
| Autor: | Tsung Shan Tsou, Tien Jui Chen, Wen Ling Lee, Chien Sheng Chen, Yuan Yi Yu, Tien Yu Ho, Wen Hsiang Su, Chia Hsuan Tan, Peng-Hui Wang |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Microbiological culture Point-of-Care Systems Gonorrhea Microarray medicine.disease_cause Sensitivity and Specificity medicine Humans Intensive care medicine Cervix sexually transmitted infections rapid diagnosis Medicine(all) Gynecology Immunoassay lcsh:R5-920 Ectopic pregnancy Staining and Labeling business.industry Pelvic pain Female infertility General Medicine Nucleic acid amplification technique medicine.disease Neisseria gonorrhoeae medicine.anatomical_structure point-of-care Female medicine.symptom lcsh:Medicine (General) business Nucleic Acid Amplification Techniques |
| Zdroj: | Journal of the Chinese Medical Association, Vol 74, Iss 10, Pp 430-434 (2011) |
| ISSN: | 1726-4901 |
| DOI: | 10.1016/j.jcma.2011.08.012 |
| Popis: | Gonorrhea ( Neisseria gonorrhoeae ) is a common sexually transmitted infection in women, with a heavy burden on female and neonatal health, because sequelae occur, such as female infertility, ectopic pregnancy, neonatal ophthalmitis and infection, and chronic pelvic pain. Prompt and appropriate antibiotic treatment can cure infection and avoid complications. However, adequate treatment is not easy, because early and rapid identification of gonorrhea is interfered with by many factors, including the complicated mixed microflora of the vagina and cervix, non-user-friendly culture systems, and lack of immediate availability of results, even with a combination of subjective complaint and high clinical suspicion. A PubMed search was conducted using the major headings of "gonorrhoea and diagnostic tool" and " Neisseria gonorrhoeae and diagnostic tool", before the end of 2010. Recently available methods for the diagnosis of gonorrhea infection in women were included, including traditional tools and advanced technology. Traditional tools such as microscopic examination and microbial culture have been used broadly; unfortunately, they have relatively lower specificity or sensitivity, and most importantly, "see-and-treat" is impossible for these infected women. Advances in technology, such as antigen detection by immunoassay and nucleic acid amplification tests (NAATs), have achieved major progress in the diagnosis of gonorrhea, because of their accuracy, convenience and time-saving aspects. However, NAATs are expensive, making their acceptance impossible in developing countries. Detection of pathogens including N. gonorrheae using microarray chips is viewed as a possible solution, because it is a relatively rapid, easy, inexpensive and sensitive tool, which makes an "identify-and-treat" or point-of-care policy possible. A rapid and affordable tool with high sensitivity and specificity for detection of gonorrhea in developing countries is still not available at the time of writing. To make a point-of-care policy possible, advanced technology for aiding diagnosis of gonorrhea is encouraged and appreciated. |
| Databáze: | OpenAIRE |
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