Linking disease symptoms and subtypes with personalized systems-based phenotypes: A proof of concept study
| Autor: | Kirstin Aschbacher, Mark A. Demitrack, Margaret E. Kemeny, Leslie J. Crofford, Amos Ben-Zvi, Emma K. Adam |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Oncology Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Fibromyalgia Adolescent Hydrocortisone Immunology Pituitary-Adrenal System Adrenocorticotropic hormone Young Adult Behavioral Neuroscience Adrenocorticotropic Hormone Internal medicine medicine Chronic fatigue syndrome Humans Disease Circadian rhythm Precision Medicine Psychoneuroendocrinology Fatigue Syndrome Chronic Models Statistical Endocrine and Autonomic Systems Chronic fatigue Middle Aged medicine.disease Comorbidity Circadian Rhythm Phenotype Endocrinology Data Interpretation Statistical Female Psychology Algorithms hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Brain, Behavior, and Immunity. 26:1047-1056 |
| ISSN: | 0889-1591 |
| DOI: | 10.1016/j.bbi.2012.06.002 |
| Popis: | A dynamic systems model was used to generate parameters describing a phenotype of Hypothalamic-Pituitary-Adrenal (HPA) behavior in a sample of 36 patients with chronic fatigue syndrome (CFS) and/or fibromyalgia (FM) and 36 case-matched healthy controls. Altered neuroendocrine function, particularly in relation to somatic symptoms and poor sleep quality, may contribute to the pathophysiology of these disorders. Blood plasma was assayed for cortisol and ACTH every 10 min for 24h. The dynamic model was specified with an ordinary differential equation using three parameters: (1) ACTH-adrenal signaling, (2) inhibitory feedback, and (3) non-ACTH influences. The model was "personalized" by estimating an individualized set of parameters from each participant's data. Day and nighttime parameters were assessed separately. Two nocturnal parameters (ACTH-adrenal signaling and inhibitory feedback) significantly differentiated the two patient subgroups ("fatigue-predominant" patients with CFS only versus "pain-predominant" patients with FM and comorbid chronic fatigue) from controls (all p's |
| Databáze: | OpenAIRE |
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