Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep
| Autor: | Kotaro Yamashiro, Airi Yoshimoto, Nobuyoshi Matsumoto, Yuji Ikegaya |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cardiac function curve Agonist medicine.drug_class media_common.quotation_subject Ramelteon Sleep REM Pharmaceutical Science Pharmacology Non-rapid eye movement sleep Melatonin Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Rate medicine Animals Circadian rhythm Rats Wistar media_common Electromyography business.industry General Medicine Olfactory Bulb Sleep in non-human animals Frontal Lobe 030104 developmental biology Indenes 030220 oncology & carcinogenesis Electrocorticography business medicine.drug Vigilance (psychology) |
| Zdroj: | Biological and Pharmaceutical Bulletin. 44:789-797 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a melatonin MT1/MT2 receptor agonist, has recently been developed to modulate sleep-wake rhythms. To date, the sleep-promoting effect of ramelteon has been widely delineated, but whether ramelteon treatment physiologically influences cardiac function is not well understood. To address this question, we recorded electrocardiograms, electromyograms, and electrocorticograms in the frontal cortex and the olfactory bulb of unrestrained rats treated with either ramelteon or vehicle. We detected vigilance states based on physiological measurements and analyzed cardiac and muscular activities. We found that during non-rapid eye movement (non-REM) sleep, heartrate variability was maintained by ramelteon treatment. Analysis of the electromyograms confirmed that neither microarousal during non-REM sleep nor the occupancy of phasic periods during REM sleep was altered by ramelteon. Our results indicate that ramelteon has a remedial effect on cardiac activity by keeping the heartrate variability and may reduce cardiac dysfunction during sleep. |
| Databáze: | OpenAIRE |
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