Four SNPS on Chromosome 9p21 Confer Risk to Premature, Familial CAD and MI in an American Caucasian Population (GeneQuest)
| Autor: | Qing Kenneth Wang, K. G. MacKinlay, Eric J. Topol, Kalil G. Abdullah, Y. Hu, Gong Qing Shen, Lin Li, Y. Yang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Population Myocardial Infarction Single-nucleotide polymorphism Coronary Artery Disease Biology Polymorphism Single Nucleotide White People Article Cohort Studies Coronary artery disease Risk Factors Polymorphism (computer science) Internal medicine Genetics medicine Humans Genetic Predisposition to Disease cardiovascular diseases Myocardial infarction Age of Onset education Genetics (clinical) Genes Dominant Genetic association education.field_of_study Models Genetic Case-control study Middle Aged medicine.disease United States Case-Control Studies Female Age of onset Chromosomes Human Pair 9 |
| Zdroj: | Annals of Human Genetics. 72:654-657 |
| ISSN: | 1469-1809 0003-4800 |
| DOI: | 10.1111/j.1469-1809.2008.00454.x |
| Popis: | Genome-wide association studies have separately identified four single nucleotide polymorphisms (SNPs) on chromosome 9p21 that confer susceptibility to coronary artery disease (CAD) and myocardial infarction (MI). This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest). We performed a case-control analysis of the GeneQuest Caucasian population with 310 cases with premature CAD and MI (average age at onset of 40.3 +/- 5.1) and 560 non-CAD controls to determine if these SNPs are associated with risk of CAD using both the population-based and family-based association study designs. The four SNPs are significantly associated with premature and familial MI and CAD in the GeneQuest Caucasian population (allelic P= 6.61 x 10(-7) to 1.87 x 10(-8)). Sib-TDT analysis showed that three of the four SNPs could confer significant susceptibility to premature CAD and MI. These results indicate that the four SNPs on chromosome 9p21 are also associated with premature, familial CAD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|