Intra HLA-D Region Recombinant Maps HLA-DR between HLA-B and HLA-D
| Autor: | J. A. Sachs, H Festenstein, Dolores Jaraquemada |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Genotype Recombinant Haplotype Immunology Fluorescent Antibody Technique Human leukocyte antigen Biology Biochemistry Epitope law.invention Consanguinity HLA Antigens law Polymorphism (computer science) Genetics HLA-DR Humans Immunology and Allergy Crossing Over Genetic Recombination Genetic Haplotype Lactoylglutathione Lyase Complement C4 General Medicine Complement C2 Molecular biology HLA-B Pedigree Blood Grouping and Crossmatching Recombinant DNA Female Lymphocyte Culture Test Mixed Complement Factor B |
| Zdroj: | Tissue Antigens. 17:43-56 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1981.tb00665.x |
| Popis: | A consanguineous family has been typed for HLA-A, B, C, D, DR and GLO, Bf, C2 and C4 and other red cell markers. The results indicate that an expected Dw7 homozygous sibling is a "Dw1"/Dw7 recombinant, probably derived from a crossing over between DR and D on the paternal haplotypes. The anomalous typings by Dw1 HTCs of the recombinant haplotype are best explained by the likely presence of an additional Lad polymorphism which could be a serologically detectable second epitope on the same molecule as the HLA-D determinant or in the form of two linked chains, one encoded by HLA-D and one by another Lad gene in the HLA haplotype. |
| Databáze: | OpenAIRE |
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