The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1

Autor:	Gary Steelman, Cathy Dantzman, Robert Toms Jacobs, David Aharony, Willam E Palmer, Russell C. Mauger, Philip D. Edwards, Vernon Alford, Frederick J Brown, Megan Murphy, Jean M. Surian, Laura E Garcia-Davenport, Debra L. Banville, Russell Bialecki, Chris Allan Veale, James R. Damewood, Andrew Shaw, Kara K. Pine, Edward P. Vacek, William L. Rumsey
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Tetrapeptide Organic Chemistry Clinical Biochemistry Molecular Sequence Data Pharmaceutical Science Peptide Alanine scanning NPR1 Biochemistry NPR2 Cyclic peptide Structure-Activity Relationship chemistry Atrial natriuretic peptide Drug Discovery cardiovascular system Molecular Medicine Amino Acid Sequence Molecular Biology Peptide sequence Receptors Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor
Zdroj:	Bioorganicmedicinal chemistry letters. 10(17)
ISSN:	0960-894X
Popis:	The cyclic peptide ANP 4-23 and the linear peptide analogue AP-811 have been shown to be selective ANP-CR antagonists. Via alanine scanning and truncation studies we sought to determine which residues in these molecules were important in their binding to the clearance receptor and the relationship between these two molecules. These studies show that several modifications to these compounds are possible which improve physical properties of these molecules while retaining high affinity for the ANP-CR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22172b61a131c9ffd56b9e7c1cb21700 https://pubmed.ncbi.nlm.nih.gov/10987424 Zobrazit plný text záznamu Full Text from ScienceDirect