Cheiloscopy and dermatoglyphics as genetic markers in the transmission of cleft lip and palate: A case-control study
| Autor: | B Sushma, Y S N Reddy, Kaniti Saujanya, J Raghavendra Kumar, M. Ghanashyam Prasad, K Niranjani |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Genetic Markers Male Parents Genetic counseling Cleft Lip Dentistry Risk Assessment 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Medicine Humans Genetic Predisposition to Disease Dermatoglyphics General Dentistry Orthodontics business.industry Significant difference Case-control study 030206 dentistry lcsh:RK1-715 Cleft Palate Type iib Phenotype Genetic marker lcsh:Dentistry Relative risk Case-Control Studies lip prints LIP PRINTS Female business Atd angles cleft lip and palate |
| Zdroj: | Journal of Indian Society of Pedodontics and Preventive Dentistry, Vol 34, Iss 1, Pp 48-54 (2016) |
| ISSN: | 1998-3905 |
| Popis: | Background: Determining the relative risk of cleft lip and palate (CL[P]) on the basis of lip prints and dermatoglyphics as genetic background may be useful for genetic counseling, and the development of future preventive measures. Aims and Objectives: (1) To analyze the various pattern types of lip prints and dermatoglyphics in parents of CL(P) children and to detect if any specific type can be contemplated as a genetic marker in the transmission of CL(P). (2) To compare these patterns with that of parents of unaffected children. Materials and Methods: 31 parents of children with CL(P) as a study group, and 31 parents of unaffected children as control group were included. Lip prints and finger prints were collected from all subjects and analysis of both patterns was carried out followed by a comparison of the patterns of unaffected parents with the controls statistically. Results: Among the mothers of the study group, type O followed by type IIa lip patterns were found to be significantly higher in upper and lower lips, and in fathers type IIa followed by type O were significantly higher. In the control group, type IIb followed by type III were higher in both fathers and mothers. Dermatoglyphic analysis of palm and finger prints revealed no significant difference in the pattern types and total ridge counts, but the Atd angle asymmetry was found to be significant between study and control group. Conclusion: Types IIa and O lip patterns, asymmetry of Atd angles can be considered as genetic markers for the transmission of CL(P) deformity to offsprings. |
| Databáze: | OpenAIRE |
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