Hemophagocytic syndrome in patients infected with the human immunodeficiency virus: A study of 15 consecutive patients
| Autor: | Elena Pisos-Álamo, Laura Suárez-Hormiga, A. Francés-Urmeneta, José Luis Pérez-Arellano, E A Verdugo-Espinosa, M N Jaén-Sánchez, Cristina Carranza-Rodríguez, P M Hernández-Cabrera |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Future studies Original Human immunodeficiency virus (HIV) Mycobacterium chelonae Signs and symptoms HIV Infections 030204 cardiovascular system & hematology medicine.disease_cause Terapia antirretroviral Lymphohistiocytosis Hemophagocytic Síndrome hemofagocítico 03 medical and health sciences 0302 clinical medicine medicine Humans In patient Retrospective Studies Pharmacology Gynecology Blastocystis biology Adult patients business.industry HIV VIH General Medicine Middle Aged biology.organism_classification Herpesvirus humano 8 Antiretroviral therapy Acquired immunodeficiency syndrome 030220 oncology & carcinogenesis Human herpes virus 8 Tropical medicine Female business Síndrome de inmunodeficiencia adquirida Hemophagocytic syndrome |
| Zdroj: | Revista Española de Quimioterapia |
| ISSN: | 1988-9518 |
| Popis: | espanolObjetivos. El sindrome hemofagocitico (HPS) se caracteriza por varios datos clinicos y biologicos derivados de la hiperproduccion de citocinas y proliferacion celular. Los objetivos fueron evaluar las caracteristicas epidemiologicas, etiologicas, clinicas y evolutivas de los pacientes con diagnostico de sindrome hemofagocitico e infeccion por VIH asi como su comparacion con los datos bibliograficos. Pacientes y metodos. Se realizo un estudio observacional descriptivo retrospectivo incluyendo todos los pacientes adultos con diagnostico de HPS e infeccion por VIH, atendidos en la Unidad de Enfermedades Infecciosas y Medicina Tropical del Hospital Universitario Insular de Las Palmas de Gran Canaria desde 1 de junio 1998 hasta 31 de diciembre de 2018. Resultados. Se analizo una serie de casos de 15 pacientes, observando un mayor porcentaje de varones con edad media de 42 anos. En cuanto a los criterios de HPS se observa que la presencia de fiebre, citopenias e hiperferritinemia era constante en todos los pacientes. Las manifestaciones clinicas neurologicas fueron frecuentes y ausente la clinica respiratoria. Se confirmo HPS en algunos pacientes sin inmunodepresion grave y carga viral indetectable. Ademas, un 40% de los casos no recibian ART. Las causas desencadenantes de HPS mas frecuentes fueron las viricas, especialmente HHV-8. Ademas, se identificaron dos nuevos agentes desencadenantes de HPS: Blastocystis dermatitidis y Mycobacterium chelonae Conclusion. La administracion de tratamiento en HPS es arbitraria lo que unido a su alta tasa de mortalidad e infradiagnostico indican la importancia de continuar realizando estudios futuros. EnglishObjectives. Hemophagocytic syndrome (HPS) is characterized by various clinical and biological data derived from cytokine hyperproduction and cell proliferation. The objectives of this study were to evaluate the epidemiological, etiological, clinical and evolutionary characteristics of patients diagnosed with hemophagocytic syndrome and HIV infection, as well as their comparison with data from the literature. Methods- A retrospective descriptive observational study was performed, including all adult patients with a diagnosis of HPS and HIV infection treated in the Infectious Diseases and Tropical Medicine Unit of the Hospital Universitario Insular, Las Palmas, Gran Canaria from June 1, 1998 to December 31, 2018. Results. An analysis of this series of case reports of 15 patients showed a higher percentage of males than females, with a mean age of 42 years. With respect to the diagnostic criteria for HPS, presence of fever, cytopenias and hyperferritinemia were a constant in all patients. Clinical neurological manifestations were frequent and clinical respiratory signs and symptoms absent. HPS was confirmed in some patients who were not severely immune-depressed and had undetectable viral loads. Furthermore, 40% of cases were not receiving ART. The most frequent triggering causes of HPS were viral, especially HHV-8. In addition, two new HPS triggers were identified: Blastocystis dermatitidis and Mycobacterium chelonae. Conclusion. Administration of treatment in HPS is arbitrary. This, together with the high mortality rate and the fact that it is underdiagnosed, indicates the importance of conducting future studies. |
| Databáze: | OpenAIRE |
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