A Comparison Between Cultivated and Conventional Limbal Stem Cell Transplantation for Stevens-Johnson Syndrome
| Autor: | Shigeru Kinoshita, Chie Sotozono, Tomo Suzuki, Tsutomu Inatomi, Leonard P. K. Ang, Noriko Koizumi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Cyclophosphamide medicine.drug_class Eye disease Limbal stem cell transplantation Limbus Corneae Corneal Diseases Limbal stem cell deficiency Humans Medicine Cells Cultured Dexamethasone business.industry Interleukin-8 Epithelium Corneal Epithelial Cells Stevens johnson medicine.disease eye diseases Surgery Adult Stem Cells Ophthalmology Stevens-Johnson Syndrome Tears Corticosteroid sense organs business Corneal scarring Stem Cell Transplantation medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 143:178-180 |
| ISSN: | 0002-9394 |
| Popis: | Purpose To compare the resolution of inflammation and long-term results of cultivated and conventional limbal stem cell transplantation (LSCT) in a patient with Stevens-Johnson syndrome (SJS). Design Interventional case report. Methods A 32-year-old man with SJS and bilateral total limbal stem cell deficiency underwent cultivated LSCT in the right eye, followed by conventional LSCT in the left eye three weeks later. The postoperative medication included dexamethasone 0.1% and ofloxacin 0.3% eyedrops and a tapering dose of systemic corticosteroid, cyclosporine, and cyclophosphamide. Tear samples were collected and analyzed for interleukin (IL) 8 levels. Results Complete corneal epithelialization was achieved 48 hours after cultivated LSCT, compared with three weeks after conventional LSCT. Ocular inflammation and IL-8 levels decreased more rapidly in the eye with cultivated LSCT. Four years after surgery, more severe corneal scarring and opacification were noted in the conventional LSCT eye. Conclusions Cultivated LSCT resulted in a better clinical result and vision, with less stromal scarring compared with conventional LSCT. |
| Databáze: | OpenAIRE |
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