Malondialdehyde as a Useful Biomarker of Low Hand Grip Strength in Community-Dwelling Stroke Patients
| Autor: | Chutima Jansakun, Kornyok Kamdee, Wanatsanan Chulrik, Warangkana Chunglok, Pongphan Pongpanitanont, Pornchai Sathirapanya, Onchuma Mueangson, Parinya Vongvaivanichakul |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty inflammatory cytokines Health Toxicology and Mutagenesis lcsh:Medicine hydrogen peroxide oxidative damage 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Article 03 medical and health sciences chemistry.chemical_compound Grip strength 0302 clinical medicine Modified Rankin Scale Malondialdehyde Internal medicine ischemic stroke medicine Humans Wasting Aged Aged 80 and over Muscle Weakness Hand Strength biology business.industry lcsh:R Public Health Environmental and Occupational Health Muscle weakness Middle Aged Stroke chemistry Catalase muscle strength biology.protein Biomarker (medicine) Female Independent Living medicine.symptom business Biomarkers 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 17 Issue 21 International Journal of Environmental Research and Public Health, Vol 17, Iss 7918, p 7918 (2020) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph17217918 |
| Popis: | The assessment of muscle strength by hand grip strength (HGS) is used to evaluate muscle weakness and wasting among stroke patients. This study aimed to investigate the association of oxidative stress/oxidative damage and inflammatory biomarkers with muscle strength and wasting, as evaluated by HGS, among community-dwelling post-stroke patients. The HGS of both paretic and non-paretic limbs was negatively associated with modified Rankin scale (mRS) values. The serum levels of catalase activity and malondialdehyde (MDA), and plasma tumor necrosis factor (TNF)-&alpha levels were significantly increased in post-stroke patients compared with non-stroke controls. Further analysis highlighted that hydrogen peroxide was positively correlated with HGS in the paretic limbs. Interestingly, an elevated MDA level, excluding advanced age and high mRS, increased the risk of low HGS in the non-paretic limbs of stroke patients. This study suggests that there is a detrimental association between MDA and muscle strength and early muscle wasting among post-stroke patients. Hence, MDA is a potentially useful biomarker of muscle weakness and wasting in post-stroke patients living in the community. |
| Databáze: | OpenAIRE |
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