The effects of aging on auditory cortical function
| Autor: | Gregg H. Recanzone |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Hearing loss Models Neurological Rodentia Audiology Auditory cortex Article Speech in noise 03 medical and health sciences 0302 clinical medicine Geriatric population biology.animal medicine Animals Humans Primate Auditory Cortex Geriatrics biology business.industry Presbycusis Sensory Systems 030104 developmental biology Models Animal Auditory Perception Macaca medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Hearing Research. 366:99-105 |
| ISSN: | 0378-5955 |
| DOI: | 10.1016/j.heares.2018.05.013 |
| Popis: | Age-related hearing loss is a prominent deficit, afflicting approximately half of the geriatric population. In many cases, the person may have no deficits in detecting sounds, but nonetheless suffers from a reduced ability to understand speech, particularly in a noisy environment. While rodent models have shown that there are a variety of age-related changes throughout the auditory neuraxis, far fewer studies have investigated the effects at the cortical level. Here I review recent evidence from a non-human primate model of age-related hearing loss at the level of the core (primary auditory cortex, A1) and belt (caudolateral field, CL) in young and aged animals with normal detection thresholds. The findings are that there is an increase in both the spontaneous and driven activity, an increase in spatial tuning, and a reduction in the temporal fidelity of the response in aged animals. These results are consistent with an age-related imbalance of excitation and inhibition in the auditory cortex. These spatial and temporal processing deficits could underlie the major complaint of geriatrics, that it is difficult to understand speech in noise. |
| Databáze: | OpenAIRE |
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